ReviewCell and tissue research2018
The storage and recall of memories in the hippocampo-cortical system.
Review in Cell and tissue research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 189 citations in OpenAlex.
- Neuropsychological differential diagnosis of Alzheimer's disease and vascular dementia: a systematic review with meta-regressions.Frontiers in aging neuroscience · 2023Pooled it
- Efficacy of Cortical-Hippocampal Target Intermittent Theta Burst Stimulation (iTBS) on Associative Memory of Schizophrenia: A Double-Blind, Randomized Sham-Controlled Trial.Neuropsychiatric disease and treatment · 2024Trial
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Hippocampal Volume Moderates the Link between Racial-Ethnic Discrimination and Early Adolescent Depression.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- The rise and deceleration of neuronal excitability in aging and Alzheimer's disease: Mechanisms, implications, and therapeutic targets.Ageing research reviews · 2026Review
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
- Goal-specific hippocampal inhibition gates learning.Nature · 2025Article
- A non-Hebbian code for episodic memory.Science advances · 2025Article
- Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations.Frontiers in neuroscience · 2025Article
- Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy.Brain communications · 2025Article
- Adverse Effects of AβBiomolecules · 2024Article
- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Frequency-specific directed connectivity between the hippocampus and parietal cortex during verbal and spatial episodic memory: an intracranial EEG replication.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice.eNeuro · 2024Article
- Review
- 4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice.Journal of neuroscience research · 2024Article
- Formation and Retrieval of Cell Assemblies in a Biologically Realistic Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Hippocampal-parietal cortex causal directed connectivity during human episodic memory formation: Replication across three experiments.bioRxiv : the preprint server for biology · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A quantitative computational theory of the operation of the hippocampus as an episodic memory system is described. The CA3 system operates as a single attractor or autoassociation network (1) to enable rapid one-trial associations between any spatial location (place in rodents or spatial view in primates) and an object or reward and (2) to provide for completion of the whole memory during recall from any part. The theory is extended to associations between time and object or reward to implement temporal order memory, which is also important in episodic memory. The dentate gyrus performs pattern separation by competitive learning to create sparse representations producing, for example, neurons with place-like fields from entorhinal cortex grid cells. The dentate granule cells generate, by the very small number of mossy fibre connections to CA3, a randomizing pattern separation effect that is important during learning but not recall and that separates out the patterns represented by CA3 firing as being very different from each other. This is optimal for an unstructured episodic memory system in which each memory must be kept distinct from other memories. The direct perforant path input to CA3 is quantitatively appropriate for providing the cue for recall in CA3 but not for learning. The CA1 recodes information from CA3 to set up associatively learned backprojections to the neocortex to allow the subsequent retrieval of information to the neocortex, giving a quantitative account of the large number of hippocampo-neocortical and neocortical-neocortical backprojections. Tests of the theory including hippocampal subregion analyses and hippocampal NMDA receptor knockouts are described and support the theory.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.