ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018
Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Bisphosphonates in Glucocorticoid-Treated Patients With Duchenne Muscular Dystrophy: A Systematic Review and Grading of the EvidenceNeurology · 2024Pooled it
- Association between vertebral fractures and comorbidities in patients with rheumatoid arthritis: a cross-sectional study.Journal of bone and mineral metabolism · 2025Article
- Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence.Journal of endocrinological investigation · 2025Article
- Urinary pentosidine as a potential biomarker of impaired bone health: a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2025Review
- Progress in research on osteoporosis secondary to SARS-CoV-2 infection.Animal models and experimental medicine · 2025Review
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- Approach to the Pediatric Patient With Glucocorticoid-Induced Osteoporosis.The Journal of clinical endocrinology and metabolism · 2025Article
- Serum proinflammatory cytokines, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and RANKL/OPG ratio in mild and severe COVID-19.BMC infectious diseases · 2024Article
- Clinical outcomes of COVID-19 infection in patients with osteoporosis: a nationwide cohort study in Korea using the common data model.Scientific reports · 2024Article
- Association Between Osteoporosis Self-Assessment Tool for Asians and Airflow Limitation in Japanese Post-Menopausal Women.International journal of chronic obstructive pulmonary disease · 2024Article
- Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis.BMC pulmonary medicine · 2023Observational
- A practical guide to the diagnosis and management of osteoporosis in childhood and adolescence.Frontiers in endocrinology · 2023Review
- The osteo-metabolic phenotype of COVID-19: an update.Endocrine · 2022Review
- Vertebral fractures at hospitalization predict impaired respiratory function during follow-up of COVID-19 survivors.Endocrine · 2022Article
- SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.Nature communications · 2022Article
- COVID-19 and hypopituitarism.Reviews in endocrine & metabolic disorders · 2022Review
- Bone health in Duchenne muscular dystrophy: clinical and biochemical correlates.Journal of endocrinological investigation · 2022Observational
- The Influence of Restrictive Pulmonary Dysfunction on Osteoporotic Thoracic Vertebral Fractures.Asian spine journal · 2021Article
- COVID-19 and the pituitary.Pituitary · 2021Review
- Part 2: When Should Bisphosphonates Be Used in Children with Chronic Illness Osteoporosis?Current osteoporosis reports · 2021Review
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Association between lung function and bone metabolism remains controversial. We found that impaired lung function was associated with vertebral fractures and bone loss in Japanese postmenopausal women. While vertebral deformities would impair lung function, respiratory dysfunction might in turn increase fracture risk, suggesting a complex bidirectional interaction.
introductionAssociation between bone metabolism and pulmonary function in the general population is controversial. The aim of this study was to investigate relationship between lung and bone parameters in elderly postmenopausal women.
methodsOne hundred and six postmenopausal women (75.6 ± 8.0 years old) who underwent spirometric tests were examined for prevalent vertebral fractures, bone mineral density (BMD), bone metabolic markers, and other metabolic indices such as urinary pentosidine.
resultsMultivariable logistic regression analyses revealed that forced vital capacity (FVC) (OR = 0.063, 95% CI: 0.011-0.352, p = 0.002) and urinary pentosidine (OR = 1.067, 95% CI: 1.020-1.117, p = 0.005) were associated with the presence of vertebral fractures after adjustment for height loss, age, and BMD at femoral neck. Moreover, vital capacity (VC) or FVC as well as body mass index and age was among independent determinants of BMD after adjustment for height loss and the number and grade of vertebral fractures in forced multiple linear regression analysis (VC: β = 0.212, p = 0.021, FVC: β = 0.217, p = 0.031). Urinary pentosidine was negatively correlated with pulmonary function parameters such as FVC and forced expiratory volume in 1 s (FEV
conclusionsDiminished FVC was associated with prevalent vertebral fractures and decreased BMD in Japanese postmenopausal women without apparent pulmonary diseases. Mechanism of such association between pulmonary function and bone status remains to be determined.
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