Evidence map›Paper›PMID 29218356›Full record

ArticleChemical communications (Cambridge, England)2018

Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering.

Rong Long, Luyuan Zhang, Lingyan Shi, Yihui Shen, Fanghao Hu, Chen Zeng, Wei Min

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
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  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Raman Spectroscopy for Chemical Biology Research.Journal of the American Chemical Society · 2022
    Review
  14. Article
  15. Miniaturized Chemical Tags for Optical Imaging.Angewandte Chemie (International ed. in English) · 2022
    Review
  16. Article
  17. Article
  18. Quantitative Stimulated Raman Scattering Microscopy: Promises and Pitfalls.Annual review of analytical chemistry (Palo Alto, Calif.) · 2022
    Review
  19. Article
  20. Nonlinear Optical Microscopy and Plasmon Enhancement.Nanomaterials (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rong LongDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.ORCID http://orcid.org/0000-0002-8238-9245
Luyuan ZhangDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.
Lingyan ShiDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.
Yihui ShenDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.
Fanghao HuDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.
Chen ZengDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.
Wei MinDepartment of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.ORCID http://orcid.org/0000-0003-2570-3557

Funding

Label-Free Chemical Imaging for Biological ApplicationsDP2EB016573 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MIN, WEI · 2012 to 2012
$2.4M
Optical imaging of small bio-molecules in living cells and tissues by nonlinear Raman microscopy coupled with vibrational tagsR01EB020892 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MIN, WEI · 2015 to 2018
$1.3M
NIBIB NIH HHS DP2 EB016573NIBIB NIH HHS R01 EB020892
6 · The paper itself

Abstract

A two-color vibrational imaging technique for simultaneously mapping glucose uptake and incorporation activity inside single living cells is reported. Heterogeneous patterns of glucose metabolism are directly visualized from the ratiometric two-color images for various cell types, cells undergoing epithelia-to-mesenchymal transitions and live mouse brain tissues. The two-color imaging of glucose metabolism here demonstrates the development of multi-functional vibrational probes for multicolor imaging of cellular metabolism.

Indexed as

AnimalsAzetidinesCarbon RadioisotopesCell Line, TumorChlorocebus aethiopsChoroid PlexusCOS CellsDeuteriumEpithelial-Mesenchymal TransitionGlucoseHumansLipogenesisMiceMolecular ImagingNitrilesNonlinear Optical Microscopy3-O-propargyl-D-glucose4-(1-(5-(3,4-dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrileAzetidinesCarbon RadioisotopesDeuteriumGlucoseNitrilesPyrazoles

Identifiers

PMID29218356
PMCPMC5764084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.