Protection of Meconium-Induced Lung Epithelial Injury by Protease Inhibitors.

C Ota, I Gopallawa, V Ivanov, I H Gewolb, B D Uhal

Open access · hybridAbstract read

In one paragraph

Article in Journal of lung, pulmonary & respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 37% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation.Animals : an open access journal from MDPI · 2022
Review
Activation of mas restores hyperoxia-induced loss of lung epithelial barrier function through inhibition of apoptosis.Journal of lung, pulmonary & respiratory research · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C OtaDepartment of Physiology, Michigan State University, USA.

I GopallawaDepartment of Physiology, Michigan State University, USA.

V IvanovCollege of Human Medicine, Department of Pediatrics, Michigan State University, USA.

I H GewolbCollege of Human Medicine, Department of Pediatrics, Michigan State University, USA.

B D UhalDepartment of Physiology, Michigan State University, USA.

Michigan State University · US

Funding

CONTROL OF TYPE II PNEUMOCYTE PROLIFERATIONR01HL045136 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI UHAL, BRUCE D · 1996 to 2012

$2.9M

NHLBI NIH HHS R01 HL045136

6 · The paper itself

Abstract

Earlier work form this laboratory showed that exposure of alveolar epithelial cells (AECs) to meconium caused significant cell detachment and that meconium-induced detachment of cells was prevented by a protease inhibitor cocktail. Therefore, it was hypothesized that protease inhibitors might protect AEC monolayers against meconium-induced collapse of epithelial barrier function both

Indexed as

Alveolar type II cellsApoptosisLocal angiotensin systemNeonatal lung injury

Identifiers

PMID29218325

PMCPMC5716639

OpenAlexW2784187403

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.