ArticleAmerican journal of cancer research2017
Elevated HBXIP expression is associated with aggressive phenotype and poor prognosis in esophageal squamous cell carcinoma.
Article in American journal of cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Research progress on oncoprotein hepatitis B X‑interacting protein (Review).Molecular medicine reports · 2024Review
- The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth.Nucleic acids research · 2020Article
- The effects of HBXIP on the biological functions of tongue squamous cell carcinoma cells and correlation with PI3K/Akt.Translational cancer research · 2020Article
- Germacrone Regulates HBXIP-Mediated Cell Cycle, Apoptosis and Promotes the Formation of Autophagosomes to Inhibit the Proliferation of Gastric Cancer Cells.Frontiers in oncology · 2020Article
- Increased Expression of LAMTOR5 Predicts Poor Prognosis and Is Associated with Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma.International journal of medical sciences · 2019Article
- The oncoprotein HBXIP facilitates metastasis of hepatocellular carcinoma cells by activation of MMP15 expression.Cancer management and research · 2019Article
- Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oncoprotein hepatitis B virus X-interacting protein (HBXIP) has been suggested to play an essential role in several malignancies. However, the clinicopathological significance and prognostic value of HBXIP expression in esophageal squamous cell carcinoma (ESCC) is still unknown. Therefore the aim of this study was to characterize HBXIP expression and its prognostic value in ESCC. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to assess the mRNA and protein expression of HBXIP in ESCC tissues and cell lines. Immunohistochemistry (IHC) was conducted to characterize the expression pattern of HBXIP in 152 archived paraffin-embedded ESCC and matched nontumorous tissues. The mRNA and protein expression of HBXIP in ESCC tissues was significantly higher than those in adjacent nontumorous tissues. High HBXIP expression was associated with histological grade (
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Identifiers
29218243PMC5714748W2982279904What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.