Evidence map›Paper›PMID 29218233›Full record

ReviewJournal of drug delivery2017

Targeted Delivery of siRNA Therapeutics to Malignant Tumors.

Qixin Leng, Martin C Woodle, A James Mixson

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
  9. Article
  10. Review
  11. Advances in delivery systems for doxorubicin.Journal of nanomedicine & nanotechnology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Qixin LengDepartment of Pathology, University of Maryland School of Medicine, 10 S. Pine St., Baltimore, MD 21201, USA.
Martin C WoodleAparna Biosciences Corporation, 9119 Gaither Rd., Gaithersburg, MD 20877, USA.
A James MixsonDepartment of Pathology, University of Maryland School of Medicine, 10 S. Pine St., Baltimore, MD 21201, USA.ORCID 0000-0002-1717-5400
University of Maryland, Baltimore · US

Funding

Ident. of Structural Features of HK Polyplexes for Imprv. siRNA Deliv. to TumorsR01CA136938 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MIXSON, ARCHIBALD JAMES · 2009 to 2012
$1.2M
NCI NIH HHS R01 CA136938
6 · The paper itself

Abstract

Over the past 20 years, a diverse group of ligands targeting surface biomarkers or receptors has been identified with several investigated to target siRNA to tumors. Many approaches to developing tumor-homing peptides, RNA and DNA aptamers, and single-chain variable fragment antibodies by using phage display,

Identifiers

PMID29218233
PMCPMC5700508
OpenAlexW2767628531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.