Evidence map›Paper›PMID 29218087›Full record

ArticleAmerican journal of translational research2017

The cytoskeleton protein β-actin may mediate T cell apoptosis during acute rejection reaction after liver transplantation in a rat model.

Xiaolong Chen, Jun Zheng, Jianye Cai, Hui Li, Shihui Li, Li Wang, Daorou Cheng, Huaxin Chen, Yang Yang, Guihua Chen and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Xiaolong ChenDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Jun ZhengDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Jianye CaiDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Hui LiDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Shihui LiDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Li WangDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Daorou ChengDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Huaxin ChenBiotherapy Center, The Third Affiliated Hospital, Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Yang YangDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Guihua ChenDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Qi ZhangDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Yanwen PengBiotherapy Center, The Third Affiliated Hospital, Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Qiyou WangDepartment of Orthopaedics, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Genshu WangDepartment of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630, Guangdong Province, China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoskeletal proteins and associated regulatory proteins are essential for maintaining cell structure and growth. β-actin is a major component of the cytoskeleton, and β-actin remodeling is involved in lymphocyte migration, infiltration and apoptosis. However, little is known about whether changes in β-actin expression affect lymphocyte cell fate, particularly during acute rejection after liver transplantation in a rat model. In our studies, grafts were harvested on days 5, 7 or 9 after xenogeneic rat liver transplantation. The acute rejection grade was histopathologically evaluated. Recipient-derived CD8

Indexed as

Acute rejectionCD8+ T lymphocyteliver transplantationβ-actin

Identifiers

PMID29218087
PMCPMC5714773
OpenAlexW2969771892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.