Evidence map›Paper›PMID 29218011›Full record

ArticleFrontiers in pharmacology2017

Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol.

Vanessa Gonzalez-Covarrubias, Javier Urena-Carrion, Beatriz Villegas-Torres, J Eduardo Cossío-Aranda, Sergio Trevethan-Cravioto, Raul Izaguirre-Avila, O Javier Fiscal-López, Xavier Soberon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mapping genes for drug chronotherapy.Drug discovery today · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vanessa Gonzalez-CovarrubiasInstituto Nacional de Medicina Genomica, Mexico City, Mexico.
Javier Urena-CarrionInstituto Nacional de Medicina Genomica, Mexico City, Mexico.
Beatriz Villegas-TorresInstituto Nacional de Medicina Genomica, Mexico City, Mexico.
J Eduardo Cossío-ArandaInstituto Nacional de Cardiologia, Mexico City, Mexico.
Sergio Trevethan-CraviotoInstituto Nacional de Cardiologia, Mexico City, Mexico.
Raul Izaguirre-AvilaInstituto Nacional de Cardiologia, Mexico City, Mexico.
O Javier Fiscal-LópezInstituto Nacional de Cardiologia, Mexico City, Mexico.
Xavier SoberonInstituto Nacional de Medicina Genomica, Mexico City, Mexico.
Instituto Nacional de Cardiología · MXNational Institute of Genomic Medicine · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on

Indexed as

acenocumarolcoumarinsMexican Mestizopharmacogenomicspopulation differencestargeted sequencing

Identifiers

PMID29218011
PMCPMC5703746
OpenAlexW2768123565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.