Evidence map›Paper›PMID 29218003›Full record

ArticleFrontiers in neural circuits2017

Eye-Drops for Activation of DREADDs.

William T Keenan, Diego C Fernandez, Lukas J Shumway, Haiqing Zhao, Samer Hattar

Abstract read
In one paragraph

Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Network Dysfunction Precedes Neurodegeneration in a dox-Regulatable TDP-43 Mouse Model of ALS-FTD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. GJournal of neurophysiology · 2020
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Photoreceptive retinal ganglion cells control the information rate of the optic nerve.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

William T KeenanBiology Department, Johns Hopkins University, Baltimore, MD, United States.
Diego C FernandezBiology Department, Johns Hopkins University, Baltimore, MD, United States.
Lukas J ShumwayNational Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States.
Haiqing ZhaoBiology Department, Johns Hopkins University, Baltimore, MD, United States.
Samer HattarNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.

Funding

Section on Light and Circadian RhythmsZIAMH002964 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI HATTAR, SAMER · 2017 to 2025
$24.1M
CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Regulation of the intrinsic melanopsin-based light response in ipRGCsR01EY027202 · NEI · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI RONALD Lane BROWN, Joseph Leffler · 2017 to 2026
$5.3M
Role of mammalian retinal photoreceptors in non-image-forming visual functionsR01GM076430 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ZHAO, HAIQING · 2005 to 2018
$4.8M
Acquisition of Sony Biotechnology iCyt Synergy SY3200 BSC Cell SorterS10OD016230 · OD · JOHNS HOPKINS UNIVERSITY · PI MCCAFFERY, J. MICHAEL · 2014 to 2014
$520k
Light direct effects on mood and cognitive functionsR21EY024452 · NEI · JOHNS HOPKINS UNIVERSITY · PI HATTAR, SAMER · 2014 to 2015
$430k
NEI NIH HHS R01 EY027202NEI NIH HHS R21 EY024452NIGMS NIH HHS R01 GM076430NIGMS NIH HHS T32 GM007231NIH HHS S10 OD016230
6 · The paper itself

Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are an important tool for modulating and understanding neural circuits. Depending on the DREADD system used, DREADD-targeted neurons can be activated or repressed

Indexed as

Ophthalmic SolutionsAnimalsBrainClozapineDependovirusDesigner DrugsFemaleGenetic VectorsGene Transfer TechniquesInjections, IntraperitonealMaleMice, 129 StrainMice, Inbred C57BLNeuronsNeurotransmitter AgentsProto-Oncogene Proteins c-fosClozapineclozapine N-oxideDesigner DrugsNeurotransmitter AgentsOphthalmic SolutionsProto-Oncogene Proteins c-fosReceptors, Neurotransmitterbehaviorchemogeneticsclozapine-N-oxideDREADDneural circuit

Identifiers

PMID29218003
PMCPMC5703865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.