Evidence map›Paper›PMID 29217819›Full record

ArticleTranslational psychiatry2017

Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects.

Johanna Hoffmann, Deborah Janowitz, Sandra Van der Auwera, Katharina Wittfeld, Matthias Nauck, Nele Friedrich, Mohamad Habes, Christos Davatzikos, Jan Terock, Martin Bahls and 4 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. The Role of GDNF and NSE in Attention-deficit/Hyperactivity Disorder: The Relationship with Sleep and Eating.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  4. Impact of Sex on Plasma Biomarkers in ob/ob Mice.International journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Johanna HoffmannDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Deborah JanowitzDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. janowitz@uni-greifswald.de.ORCID http://orcid.org/0000-0003-4324-9298
Sandra Van der AuweraDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Katharina WittfeldGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock, Greifswald, Germany.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Nele FriedrichInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Mohamad HabesDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-9447-5805
Christos DavatzikosDepartment of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA.
Jan TerockDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Stralsund, Germany.
Martin BahlsDZHK (German Centre for Cardiovascular Research), Partner site Greifswald, Greifswald, Germany.
Annemarie GoltzDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Angela KuhlaInstitute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany.
Henry VölzkeDZHK (German Centre for Cardiovascular Research), Partner site Greifswald, Greifswald, Germany.
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Universitätsmedizin Greifswald · DEGerman Center for Neurodegenerative Diseases · DEUniversity of Pennsylvania · USUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum neuron-specific enolase (sNSE) is considered a marker for neuronal damage, related to gray matter structures. Previous studies indicated its potential as marker for structural and functional damage in conditions with adverse effects to the brain like obesity and dementia. In the present study, we investigated the putative association between sNSE levels, body mass index (BMI), total gray matter volume (GMV), and magnetic resonance imaging-based indices of aging as well as Alzheimer's disease (AD)-like patterns. SUBJECTS/

methodssNSE was determined in 901 subjects (499 women, 22-81 years, BMI 18-48 kg/m

Indexed as

AdultAgedAged, 80 and overAge FactorsBody Mass IndexBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOverweightPhosphopyruvate HydrataseSex CharacteristicsYoung AdultPhosphopyruvate Hydratase

Identifiers

PMID29217819
PMCPMC5802579
OpenAlexW2771677758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.