Evidence map›Paper›PMID 29217742›Full record

ArticleAJNR. American journal of neuroradiology2018

Diagnostic Accuracy of Centrally Restricted Diffusion in the Differentiation of Treatment-Related Necrosis from Tumor Recurrence in High-Grade Gliomas.

N Zakhari, M S Taccone, C Torres, S Chakraborty, J Sinclair, J Woulfe, G H Jansen, T B Nguyen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

N ZakhariFrom the Department of Radiology (N.Z., C.T., S.C., T.B.N.), Division of Neuroradiology, University of Ottawa, The Ottawa Hospital Civic and General Campus, Ottawa, Ontario, Canada.ORCID 0000-0002-9990-2420
M S TacconeDivision of Neurosurgery (M.S.T., J.S.).ORCID 0000-0002-9521-4743
C TorresFrom the Department of Radiology (N.Z., C.T., S.C., T.B.N.), Division of Neuroradiology, University of Ottawa, The Ottawa Hospital Civic and General Campus, Ottawa, Ontario, Canada.ORCID 0000-0003-4104-7115
S ChakrabortyFrom the Department of Radiology (N.Z., C.T., S.C., T.B.N.), Division of Neuroradiology, University of Ottawa, The Ottawa Hospital Civic and General Campus, Ottawa, Ontario, Canada.ORCID 0000-0002-2975-2260
J SinclairDivision of Neurosurgery (M.S.T., J.S.).ORCID 0000-0002-1962-0934
J WoulfeDepartment of Pathology and Laboratory Medicine (J.W., G.H.J.), University of Ottawa, The Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada.ORCID 0000-0002-7382-6343
G H JansenDepartment of Pathology and Laboratory Medicine (J.W., G.H.J.), University of Ottawa, The Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada.ORCID 0000-0002-4316-7666
T B NguyenFrom the Department of Radiology (N.Z., C.T., S.C., T.B.N.), Division of Neuroradiology, University of Ottawa, The Ottawa Hospital Civic and General Campus, Ottawa, Ontario, Canada thnguyen@toh.ca.ORCID 0000-0001-8458-3351
University of Ottawa · CAHesco (United States) · USOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCentrally restricted diffusion has been demonstrated in recurrent high-grade gliomas treated with bevacizumab. Our purpose was to assess the accuracy of centrally restricted diffusion in the diagnosis of radiation necrosis in high-grade gliomas not treated with bevacizumab. MATERIALS AND

methodsIn this prospective study, we enrolled patients with high-grade gliomas who developed a new ring-enhancing necrotic lesion and who underwent re-resection. The presence of a centrally restricted diffusion within the ring-enhancing lesion was assessed visually on diffusion trace images and by ADC measurements on 3T preoperative diffusion tensor examination. The percentage of tumor recurrence and radiation necrosis in each surgical specimen was defined histopathologically. The association between centrally restricted diffusion and radiation necrosis was assessed using the Fisher exact test. Differences in ADC and the ADC ratio between the groups were assessed via the Mann-Whitney

resultsSeventeen patients had re-resected ring-enhancing lesions: 8 cases of radiation necrosis and 9 cases of tumor recurrence. There was significant association between centrally restricted diffusion by visual assessment and radiation necrosis (

conclusionsThe presence of centrally restricted diffusion in a new ring-enhancing lesion might indicate radiation necrosis rather than tumor recurrence in high-grade gliomas previously treated with standard chemoradiation without bevacizumab.

Indexed as

AdultAgedBrain NeoplasmsDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleGliomaHumansMaleMiddle AgedNecrosisNeoplasm Recurrence, LocalProspective StudiesRadiation InjuriesROC CurveSensitivity and Specificity

Identifiers

PMID29217742
PMCPMC7410592
OpenAlexW2773240551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.