ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Repositioning of Somatic Golgi Apparatus Is Essential for the Dendritic Establishment of Adult-Born Hippocampal Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The Functions of the Golgin Family of Coiled-Coil Proteins.Sub-cellular biochemistry · 2026Review
- The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for Hereditary Spastic Paraplegia.Progress in neurobiology · 2024Article
- The neuronal Golgi in neural circuit formation and reorganization.Frontiers in neural circuits · 2024Review
- The organization and function of the Golgi apparatus in dendrite development and neurological disorders.Genes & diseases · 2023Review
- Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation.Antioxidants (Basel, Switzerland) · 2023Review
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- Lanthanum Chloride Induces Axon Abnormality Through LKB1-MARK2 and LKB1-STK25-GM130 Signaling Pathways.Cellular and molecular neurobiology · 2023Article
- Progression of Alzheimer's disease parallels unusual structural plasticity of human dentate granule cells.Acta neuropathologica communications · 2022Article
- STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV.Cell death discovery · 2021Article
- Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites.Molecular biology of the cell · 2021Article
- De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation.American journal of human genetics · 2020Article
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- Early Dendritic Morphogenesis of Adult-Born Dentate Granule Cells Is Regulated by FHL2.Frontiers in neuroscience · 2020Article
- Multimodal Analysis of STRADA Function in Brain Development.Frontiers in cellular neuroscience · 2020Article
- Lateral dispersion is required for circuit integration of newly generated dentate granule cells.Nature communications · 2019Article
- Review
- Golgi Complex Dynamics and Its Implication in Prevalent Neurological Disorders.Frontiers in cell and developmental biology · 2019Review
- Asymmetric Golgi Repositioning: A Prerequisite for Appropriate Dendrite Formation in Adult-Born Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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7 authors at 2 institutions in 1 country.
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Abstract
New dentate granule cells (DGCs) are continuously generated, and integrate into the preexisting hippocampal network in the adult brain. How an adult-born neuron with initially simple spindle-like morphology develops into a DGC, consisting of a single apical dendrite with further branches, remains largely unknown. Here, using retroviruses to birth date and manipulate newborn neurons, we examined initial dendritic formation and possible underlying mechanisms. We found that GFP-expressing newborn cells began to establish a DGC-like morphology at ∼7 d after birth, with a primary dendrite pointing to the molecular layer, but at this stage, with several neurites in the neurogenic zone. Interestingly, the Golgi apparatus, an essential organelle for neurite growth and maintenance, was dynamically repositioning in the soma of newborn cells during this initial integration stage. Two weeks after birth, by which time most neurites in the neurogenic zone were eliminated, a compact Golgi apparatus was positioned exclusively at the base of the primary dendrite. We analyzed the presence of Golgi-associated genes using single-cell transcriptomes of newborn DGCs, and among Golgi-related genes, found the presence of
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