Evidence map›Paper›PMID 29217678›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

HRPU-2, a Homolog of Mammalian hnRNP U, Regulates Synaptic Transmission by Controlling the Expression of SLO-2 Potassium Channel in

Ping Liu, Sijie Jason Wang, Zhao-Wen Wang, Bojun Chen

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ping LiuDepartment of Neuroscience, UConn Health, Farmington Connecticut 06030-3401, and.
Sijie Jason WangDepartment of Hospital Medicine, Concord Hospital, Concord, New Hampshire 03301.
Zhao-Wen WangDepartment of Neuroscience, UConn Health, Farmington Connecticut 06030-3401, and.ORCID 0000-0003-3574-8556
Bojun ChenDepartment of Neuroscience, UConn Health, Farmington Connecticut 06030-3401, and bochen@uchc.edu.ORCID 0000-0002-1141-9101
UConn Health · USConcord Hospital · US

Funding

Synaptic function of BK channel-interacting proteinsR01MH085927 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHAO-WEN WANG · 2010 to 2026
$6.7M
Novel proteins regulating function and expression of SLO-2 potassium channelsR01GM113004 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CHEN, BOJUN · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM113004NIMH NIH HHS R01 MH085927
6 · The paper itself

Abstract

Slo2 channels are large-conductance potassium channels abundantly expressed in the nervous system. However, it is unclear how their expression level in neurons is regulated. Here we report that HRPU-2, an RNA-binding protein homologous to mammalian heterogeneous nuclear ribonucleoprotein U (hnRNP U), plays an important role in regulating the expression of SLO-2 (a homolog of mammalian Slo2) in

Indexed as

Amino Acid SequenceAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsEpilepsyGene Expression RegulationHeterogeneous-Nuclear Ribonucleoprotein UHumansIntellectual DisabilityMembrane Transport ProteinsMotor ActivityMotor NeuronsMutationSynaptic TransmissionCaenorhabditis elegans ProteinsHeterogeneous-Nuclear Ribonucleoprotein UMembrane Transport ProteinsSLO-2 protein, C elegansC. eleganshnRNP UHRPU-2SLO-2synaptic transmission

Identifiers

PMID29217678
PMCPMC5792471
OpenAlexW2774459093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.