Evidence map›Paper›PMID 29217611›Full record

Observational studyThe European respiratory journal2017

Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study.

Coralynn Sack, Sverre Vedal, Lianne Sheppard, Ganesh Raghu, R Graham Barr, Anna Podolanczuk, Brent Doney, Eric A Hoffman, Amanda Gassett, Karen Hinckley-Stukovsky and 4 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 6 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 6 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Fibrotic interstitial lung diseases and air pollution: a systematic literature review.European respiratory review : an official journal of the European Respiratory Society · 2020
    Pooled it
  6. Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019
    Pooled it
  7. Review
  8. Health effects of air pollution on chronic respiratory diseases.The Korean journal of internal medicine · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Air pollution and alveolar health.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  17. Article
  18. Current perspectives on interstitial lung abnormalities.The Korean journal of internal medicine · 2025
    Review
  19. Review
  20. Genomic and Serological Rheumatoid Arthritis Biomarkers,Annals of the American Thoracic Society · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Coralynn SackDept of Medicine, University of Washington, Seattle, WA, USA.
Sverre VedalDept of Medicine, University of Washington, Seattle, WA, USA.
Lianne SheppardDept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Ganesh RaghuDept of Medicine, Center for Interstitial Lung Diseases, University of Washington Medical Center, Seattle, WA, USA.
R Graham BarrDept of Medicine, Columbia University Medical Center, New York, NY, USA.
Anna PodolanczukDept of Medicine, Columbia University Medical Center, New York, NY, USA.
Brent DoneyRespiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.
Eric A HoffmanDept of Radiology, Carver School of Medicine, University of Iowa, Iowa City, IA, USA.
Amanda GassettDept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Karen Hinckley-StukovskyDept of Biostatistics, University of Washington, Seattle, WA, USA.
Kayleen WilliamsCollaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA.
Steve KawutDepts of Medicine and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David J LedererDept of Medicine, Columbia University Medical Center, New York, NY, USA dl427@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-5258-0228
Joel D KaufmanDept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
University of Washington · USColumbia University Irving Medical Center · USNational Institute for Occupational Safety and Health · USUniversity of Iowa · USUniversity of Pennsylvania · USUniversity of Washington Medical Center · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI CATHERINE J KARR · 1995 to 2026
$42.5M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
Project 5: ROS, Glutathione and Vascular Response to Diesel ExhaustP50ES015915 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAUFMAN, JOEL DANIEL · 2008 to 2012
$11.8M
Subclinical Interstitial Lung Disease in MESA and FAR-ILDR01HL103676 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GARCIA, CHRISTINE KIM · 2011 to 2020
$6.4M
Multi-center Structural & Functional Quantitative CT Pulmonary PhenotypingR01HL112986 · NHLBI · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2012 to 2016
$4.6M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Environmental Factors in Cardiovascular DiseaseK24ES013195 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAUFMAN, JOEL DANIEL · 2005 to 2014
$1.5M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
Intramural CDC HHS CC999999NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS K24 HL131937NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL103676NHLBI NIH HHS R01 HL112986NHLBI NIH HHS T32 HL007287NIEHS NIH HHS K24 ES013195NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P50 ES015915
6 · The paper itself

Abstract

We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT).We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM

Indexed as

Tomography, X-Ray ComputedAgedAir PollutionEnvironmental ExposureEthnicityFemaleHumansLogistic ModelsLung Diseases, InterstitialMaleMiddle AgedMultivariate AnalysisNitrogen DioxideNitrogen OxidesOzoneParticulate MatterNitrogen DioxideNitrogen OxidesOzoneParticulate Matter

Identifiers

PMID29217611
PMCPMC5726423
OpenAlexW2773677769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.