Evidence map›Paper›PMID 29217579›Full record

ArticleScience (New York, N.Y.)2017

Structural basis for methylphosphonate biosynthesis.

David A Born, Emily C Ulrich, Kou-San Ju, Spencer C Peck, Wilfred A van der Donk, Catherine L Drennan

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Diverse marineMarine life science & technology · 2025
    Article
  5. Article
  6. Profile of Catherine Drennan.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

David A BornGraduate Program in Biophysics, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3507-9022
Emily C UlrichDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-0468-6615
Kou-San JuCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0003-0438-6740
Spencer C PeckDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-1599-6635
Wilfred A van der DonkDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-5467-7071
Catherine L DrennanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-5486-2755
University of Illinois Urbana-Champaign · USHoward Hughes Medical Institute · USHarvard University · US

Funding

Structural Elucidation and Biosynthesis P01GM077596 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2007 to 2016
$15.3M
MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Request for a Varian 600 MHz NMR InstrumentS10RR028833 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2011 to 2011
$600k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR028833NCRR NIH HHS S10 RR029205NIGMS NIH HHS P01 GM077596NIGMS NIH HHS P41 GM103403NIGMS NIH HHS T32 GM008313
6 · The paper itself

Abstract

Methylphosphonate synthase (MPnS) produces methylphosphonate, a metabolic precursor to methane in the upper ocean. Here, we determine a 2.35-angstrom resolution structure of MPnS and discover that it has an unusual 2-histidine-1-glutamine iron-coordinating triad. We further solve the structure of a related enzyme, hydroxyethylphosphonate dioxygenase from

Indexed as

AlphaproteobacteriaAquatic OrganismsBacterial ProteinsCatalytic DomainGlutamineHistidineMicrobiotaOrganophosphorus CompoundsOxygenasesPhylogenyStreptomycesBacterial ProteinsGlutamineHistidinemethylphosphonic acidOrganophosphorus CompoundsOxygenases

Identifiers

PMID29217579
PMCPMC5901744
OpenAlexW2773645257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.