Evidence map›Paper›PMID 29217432›Full record

ArticleJournal of molecular and cellular cardiology2018

Transverse tubular network structures in the genesis of intracellular calcium alternans and triggered activity in cardiac cells.

Zhen Song, Michael B Liu, Zhilin Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Mechanisms of spontaneous CaThe Journal of physiology · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhen SongDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: zsong@mednet.ucla.edu.
Michael B LiuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Zhilin QuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: zqu@mednet.ucla.edu.

Funding

WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES N · 2005 to 2015
$20.7M
Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
Rationale for the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) at Children?s NationalT32HL110841 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI Catherine M. Bollard, NAOMI L LUBAN · 2012 to 2026
$2.0M
Systems Modeling of Cardiac Excitation-Contraction-Metabolism CouplingR56HL118041 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2014 to 2014
$358k
Triggered arrhythmias induced by heart failure remodeling: A multi-scale computational approachF30HL132449 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIU, MICHAEL BON-HAO · 2016 to 2019
$163k
NHLBI NIH HHS F30 HL132449NHLBI NIH HHS P01 HL078931NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R56 HL118041NHLBI NIH HHS T32 HL110841
6 · The paper itself

Abstract

rationaleThe major role of a transverse-tubular (TT) network in a cardiac cell is to facilitate effective excitation-contraction coupling and signaling. The TT network structures are heterogeneous within a single cell, and vary between different types of cells and species. They are also remodeled in cardiac diseases. However, how different TT network structures predispose cardiac cells to arrhythmogenesis remains to be revealed.

objectiveTo systematically investigate the roles of TT network structure and the underlying mechanisms in the genesis of intracellular calcium (Ca METHODS AND

resultsBased on recent experimental observations, different TT network structures, including uniformly and non-uniformly random TT distributions, were modeled in a cardiac cell model consisting of a three-dimensional network of Ca

conclusionsThe TT network plays important roles in promoting Ca

Indexed as

Calcium SignalingCalcium Channels, L-TypeCell SizeHeart AtriaHeart VentriclesIntracellular SpaceModels, CardiovascularMyocytes, CardiacSarcoplasmic ReticulumSodium-Calcium ExchangerCalcium Channels, L-TypeSodium-Calcium ExchangerAlternansCalcium cyclingCell sizeTriggered activityT-tubules

Identifiers

PMID29217432
PMCPMC5801147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.