ArticleAnnals of epidemiology2018
Mediating effects of cancer risk factors on the association between race and cancer incidence: analysis of the NIH-AARP Diet and Health Study.
Article in Annals of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Serum markers, obesity and prostate cancer risk: results from the prostate cancer prevention trial.Endocrine-related cancer · 2022Trial
- Identifying clinical and lifestyle factor mediators of the association between socioeconomic status and colorectal cancer mortality.SSM - population health · 2026Article
- Associations of Albumin and BMI with Colorectal Cancer Risk in the Southern Community Cohort Study: a Prospective Cohort Study.Journal of racial and ethnic health disparities · 2024Article
- Impact of Alcohol Consumption on Breast Cancer Incidence and Mortality: The Women's Health Study.Journal of women's health (2002) · 2024Article
- Neighborhood Disadvantage, African Genetic Ancestry, Cancer Subtype, and Mortality Among Breast Cancer Survivors.JAMA network open · 2023Article
- Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer.Endocrine-related cancer · 2023Article
- Cancer Risk in a Large Inception Systemic Lupus Erythematosus Cohort: Effects of Demographic Characteristics, Smoking, and Medications.Arthritis care & research · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeRacial disparities exist in the prevalence of cancer-related risk factors and incidence of cancer. The objective of this study is to determine if cancer-related risk factors mediate the association between race and cancer incidence.
methodsWe performed prospective analysis of data from the National Institutes of Health-American Association of Retired Persons Diet and Health Study, years 1995 through 2011. We compared differences in baseline characteristics between black and white participants using χ
resultsAmong 425,152 participants, 16,110 (3.79%) were black, and 409,042 (96.21%) were white. The white participants were more likely to be aged 65 years and older (35.33% vs. 25.93%), male (60.88% vs. 42.67%), married (70.37% vs. 48.26%), reside in Western US (30.14% vs. 23.88%), be physically active (46.72% vs. 41.94%), and have higher adherence scores (3.14 vs. 3.04). Blacks had reduced risk of breast cancer (adjusted hazard ratio [HR]: 0.82, 95% confidence intervals [CI]: 0.74-0.90) but higher risk of prostate (adjusted HR: 1.86, 95% CI: 1.75-1.98) and colorectal cancer (adjusted HR: 1.17, 95% CI: 1.05-1.31) compared with whites. Nutrition mediated the association between race and breast cancer (6.35% mediated, P < .01), whereas BMI mediated the association between race and colorectal cancer (7.99% mediated, P < .01).
conclusionsBlacks were at reduced risk of breast cancer but increased risks for prostate and colorectal cancer incidence. Nutrition and BMI exerted small but significant mediating effects on the racial disparity in risk of breast and colorectal cancers, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.