ArticleJournal of biomechanics2018
Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone.
Article in Journal of biomechanics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Permeability of bone and cartilage, and stiffness of collagen within cartilage, influence osteochondral fluid transport during cyclic compression: A study in finite elements.Journal of the mechanical behavior of biomedical materials · 2026Article
- Mechanical deformations of bone generate interstitial fluid flow at nanoscale velocities around osteocytes.Frontiers in bioengineering and biotechnology · 2025Article
- Prediction of Bone Remodeling in Rat Caudal Vertebrae Based on Fluid-Solid Coupling Simulation.Annals of biomedical engineering · 2024Article
- Spatial variations in the osteocyte lacuno-canalicular network density and analysis of the connectomic parameters.PloS one · 2024Article
- Derivation, validation, and prediction of loading-induced mineral apposition rates at endocortical and periosteal bone surfaces based on fluid velocity and pore pressure.Bone reports · 2023Article
- Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants.Bioactive materials · 2023Article
- Using Finite Element Modeling in Bone Mechanoadaptation.Current osteoporosis reports · 2023Review
- The feasibility study of XACT imaging for characterizing osteoporosis.Medical physics · 2022Article
- Changes in interstitial fluid flow, mass transport and the bone cell response in microgravity and normogravity.Bone research · 2022Review
- Temporal changes in cortical microporosity during estrogen deficiency associated with perilacunar resorption and osteocyte apoptosis: A pilot study.Bone reports · 2022Article
- Osteoporosis: current screening methods, novel techniques, and preoperative assessment of bone mineral density.Bone & joint research · 2021Article
- Osteocytes and Estrogen Deficiency.Current osteoporosis reports · 2021Review
- Article
- Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Network architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons.Biomechanics and modeling in mechanobiology · 2020Article
- Control of Bone Matrix Properties by Osteocytes.Frontiers in endocrinology · 2020Review
- An Early Myeloma Bone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the Extracellular Matrix.Journal of oncology · 2020Article
- Investigating Osteocytic Perilacunar/Canalicular Remodeling.Current osteoporosis reports · 2019Review
- Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone.Journal of the Royal Society, Interface · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Loading-induced interstitial fluid flow in the microporosities of bone is critical for osteocyte mechanotransduction and for the maintenance of tissue health, enhancing convective transport in the lacunar-canalicular system. In recent studies, our group has reported alterations of bone's vascular porosity and lacunar-canalicular system microarchitecture in a rat model of postmenopausal osteoporosis. In this work, poroelastic finite element analysis was used to investigate whether these microstructural changes can affect interstitial fluid flow around osteocytes. Animal-specific finite element models were developed combining micro-CT reconstructions of bone microstructure and measures of the poroelastic material properties. These models were used to quantify and compare loading-induced fluid flow in the lacunar-canalicular system of ovariectomized and sham-operated rats. A parametric analysis was also used to quantify the influence of the lacunar-canalicular permeability and vascular porosity on the fluid velocity magnitude. Results show that mechanically-induced interstitial fluid velocity can be significantly reduced in the lacunar-canalicular system of ovariectomized rats. Interestingly, the vascular porosity is shown to have a major influence on interstitial fluid flow, while the lacunar-canalicular permeability influence is limited when larger than 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.