ArticleJournal of medical case reports2017
Dengue hemorrhagic fever complicated with acute liver failure: a case report.
Article in Journal of medical case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Intravenous N-Acetylcysteine in Patients With Dengue Fever With Marked Aminotransferase Elevation: Prospective Comparative Study.Interactive journal of medical research · 2026Article
- Fulminant Hepatic Failure in Dengue Infection: Two Survivors From a Resource-Limited Outbreak in Sudan.Clinical case reports · 2026Article
- Decoding prognosis in dengue-induced hepatitis: Model for end-stage liver diseaseWorld journal of gastroenterology · 2025Article
- Pathophysiology and clinical implications of dengue-associated neurological disorders.Frontiers in microbiology · 2025Review
- Nine fatal cases of dengue: a case series from an intensive care unit in Sri Lanka.Tropical medicine and health · 2024Article
- Dengue-related acute liver failure-A scoping review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Dengue induced acute liver failure: A meta summary of case reports.World journal of virology · 2024Article
- Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective.Translational gastroenterology and hepatology · 2024Article
- Blood transfusion in severe dengue infection: a case series.Journal of medical case reports · 2023Article
- Comodulation of Dengue and Chikungunya Virus Infection During a Coinfection Scenario in Human Cell Lines.Frontiers in cellular and infection microbiology · 2022Article
- Use of intravenous N-acetylcysteine in acute severe hepatitis due to severe dengue infection: a case series.BMC infectious diseases · 2021Article
- Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report.Journal of medical case reports · 2020Article
- Case Report: A Case of Acute Intravascular Hemolysis in Dengue Fever.The American journal of tropical medicine and hygiene · 2020Article
- Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure.Hepatic medicine : evidence and research · 2020Review
- Zika Virus Induced More Severe Inflammatory Response Than Dengue Virus in Chicken Embryonic Livers.Frontiers in microbiology · 2019Article
- Article
- N-acetylcysteine for non-acetaminophen induced acute liver failure: A review.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue is a common arboviral infection with a clinically diverse spectrum of presentations. Although hepatic dysfunction is commonly identified in patients will dengue illness, acute liver failure is rare. The etiopathogenesis of hepatic dysfunction is multifactorial and related to direct viral invasion of hepatocytes, immunological factors and hypoxia particularly in cases of shock in dengue hemorrhagic fever. Ideal management of dengue-related hepatic dysfunction and acute liver failure is still debated. CASE PRESENTATION: We report a 53-year-old Sri Lankan Sinhalese male with serologically confirmed dengue fever presenting with evidence of plasma leakage developing acute liver failure evidenced by deranged liver functions, coagulopathy and altered sensorium. In addition to the 'standard care', the patient was managed with intravenous N-acetyl cysteine and blood transfusions even in the absence of bleeding or dropping packed cell volume (PCV), targeting a higher PCV in anticipation of better oxygenation at tissue level. He made a full recovery with no sequential infections.
conclusionN-acetyl cysteine and packed cell transfusion aiming at a higher PCV to maintain adequate tissue perfusion during shock may be beneficial in acute liver failure due to dengue virus. Large randomized trials should be carried out to establish the efficacy of these treatment strategies to support these observations and change the current practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.