Evidence map›Paper›PMID 29216887›Full record

ArticleLipids in health and disease2017

Comparative analyses of DHA-Phosphatidylcholine and recombination of DHA-Triglyceride with Egg-Phosphatidylcholine or Glycerylphosphorylcholine on DHA repletion in n-3 deficient mice.

Fang Wu, Dan-Dan Wang, Min Wen, Hong-Xia Che, Chang-Hu Xue, Teruyoshi Yanagita, Tian-Tian Zhang, Yu-Ming Wang

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Fang WuCollege of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, China.
Dan-Dan WangCollege of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, China.
Min WenInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng, 252059, China.
Hong-Xia CheCollege of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, China.
Chang-Hu XueCollege of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, China.
Teruyoshi YanagitaLaboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga, 840-8502, Japan.
Tian-Tian ZhangCollege of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, China. zhangtiantian@ouc.edu.cn.
Yu-Ming WangCollege of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, China. wangyuming@ouc.edu.cn.
Ocean University of China · CNLiaocheng University · CNQingdao National Laboratory for Marine Science and Technology · CNSaga University · JP

Funding

Fundamental Research Funds for the Central Universities No. 201762028National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers U1606403State Key Program of National Natural Science of China No. 31330060the National Natural Science Foundation of China No. 31371757
6 · The paper itself

Abstract

backgroundDocosahexaenoic acid (DHA) is important for optimal neurodevelopment and brain function during the childhood when the brain is still under development.

methodsThe effects of DHA-Phosphatidylcholine (DHA-PC) and the recombination of DHA-Triglyceride with egg PC (DHA-TG + PC) or α-Glycerylphosphorylcholine (DHA-TG + α-GPC) were comparatively analyzed on DHA recovery and the DHA accumulation kinetics in tissues including cerebral cortex, erythrocyte, liver, and testis were evaluated in the weaning n-3 deficient mice.

resultsThe concentration of DHA in weaning n-3 deficient mice could be recovered rapidly by dietary DHA supplementation, in which DHA-PC exhibited the better efficacy than the recombination of DHA-Triglyceride with egg PC or α-GPC. Interestingly, DHA-TG + α-GPC exhibited the greater effect on DHA accumulation than DHA-TG + PC in cerebral cortex and erythrocyte (p < 0.05), which was similar to DHA-PC. Meanwhile, DHA-TG + PC showed a similar effect to DHA-PC on DHA repletion in testis, which was better than that of DHA-TG + α-GPC (p < 0.05).

conclusionWe concluded that different forms of DHA supplements could be applied targetedly based on the DHA recovery in different tissues, although the supplemental effects of the recombination of DHA-Triglyceride with egg PC or α-GPC were not completely equivalent to that of DHA-PC, which could provide some references to develop functional foods to support brain development and function.

Indexed as

Dietary SupplementsAnimalsCerebral CortexChickensDocosahexaenoic AcidsEggsErythrocytesFatty Acids, Omega-3GlycerylphosphorylcholineLiverMaleMiceMice, Inbred ICROrgan SpecificityPhosphatidylcholinesTestisDocosahexaenoic AcidsFatty Acids, Omega-3GlycerylphosphorylcholinePhosphatidylcholinesTriglyceridesDHA-PhosphatidylcholineN-3 Fatty acid deficiencyRepletionTissue accretion kineticsWeaning

Identifiers

PMID29216887
PMCPMC5721541
OpenAlexW2772893056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.