ArticlePLoS pathogens2017
Novel Wolbachia-transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insecticide resistance of Dengue vectors in South East Asia: a systematic review.African health sciences · 2021Pooled it
- Impact of temperature on patient-derived dengue virus breakthrough infections in wMel-infected Aedes aegypti.PLoS neglected tropical diseases · 2026Article
- Research Trends and Collaborative Patterns inInternational journal of environmental research and public health · 2026Article
- Insect Lipid Metabolism in the Presence of Symbiotic and Pathogenic Viruses and Bacteria.Advances in experimental medicine and biology · 2026Review
- Microbiome diversity in mosquitoes and sand flies: implications for vector competence.Parasites & vectors · 2025Review
- Review
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Development of the Incompatible Insect Technique targetingApplied and environmental microbiology · 2025Article
- Article
- Molecular detection of Wolbachia sp. and Cytoplasmic incompatibility factors (CifA/B) in wild caught mosquitoes in Côte d'Ivoire.Molecular biology reports · 2025Article
- Life table variations inFrontiers in insect science · 2025Article
- Review
- Article
- AntiviralmBio · 2024Article
- DENV-1 Titer Impacts Viral Blocking inViruses · 2024Article
- Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.Nature communications · 2024Article
- Detection of Natural Wolbachia Strains in Anopheles Mosquitoes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Detection and quantification of naturalFrontiers in cellular and infection microbiology · 2024Article
- Wolbachia wMel strain-mediated effects on dengue virus vertical transmission from Aedes aegypti to their offspring.Parasites & vectors · 2023Article
- Differences in proteome perturbations caused by the Wolbachia strain wAu suggest multiple mechanisms of Wolbachia-mediated antiviral activity.Scientific reports · 2023Article
18 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Wolbachia pipientis from Drosophila melanogaster (wMel) is an endosymbiotic bacterium that restricts transmission of human pathogenic flaviviruses and alphaviruses, including dengue, Zika, and chikungunya viruses, when introduced into the mosquito vector Aedes aegypti. To date, wMel-infected Ae. aegypti have been released in field trials in 5 countries to evaluate the effectiveness of this strategy for disease control. Despite the success in establishing wMel-infected mosquitoes in wild populations, and the well-characterized antiviral capabilities of wMel, transinfecting different or additional Wolbachia strains into Ae. aegypti may improve disease impact, and perhaps more importantly, could provide a strategy to account for the possible evolution of resistant arboviruses. Here, we report the successful transinfection of Ae. aegypti with the Wolbachia strains wMelCS (D. melanogaster), wRi (D. simulans) and wPip (Culex quinquefasciatus) and assess the effects on Ae. aegypti fitness, cytoplasmic incompatibility, tissue tropism and pathogen blocking in a laboratory setting. The results demonstrate that wMelCS provides a similar degree of protection against dengue virus as wMel following an infectious blood meal, and significantly reduces viral RNA levels beyond that of wMel following a direct challenge with infectious virus in mosquitoes, with no additional fitness cost to the host. The protection provided by wRi is markedly weaker than that of wMelCS, consistent with previous characterisations of these lines in Drosophila, while wPip was found to substantially reduce the fitness of Ae. aegypti. Thus, we determine wMelCS as a key candidate for further testing in field-relevant fitness tests and viremic blood feeding challenges in a clinical setting to determine if it may represent an alternative Wolbachia strain with more desirable attributes than wMel for future field testing.
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