Evidence map›Paper›PMID 29216308›Full record

ArticlePloS one2017

Candida albicans orf19.3727 encodes phytase activity and is essential for human tissue damage.

Paul Wai-Kei Tsang, Wing-Ping Fong, Lakshman Perera Samaranayake

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Divergent Approaches to Virulence inInternational journal of molecular sciences · 2019
    Review
  3. Article
  4. Article
  5. Antimicrobial agents and chemotherapy · 2018
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Paul Wai-Kei TsangTechnological and Higher Education Institute of Hong Kong, HKSAR, China.ORCID http://orcid.org/0000-0001-9163-4217
Wing-Ping FongSchool of Life Sciences, The Chinese University of Hong Kong, HKSAR, China.
Lakshman Perera SamaranayakeCollege of Dental Medicine, University of Sharjah, University City, United Arab Emirates.
Chinese University of Hong Kong · HKTechnological and Higher Education Institute of Hong Kong · HKUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida albicans is a clinically important human fungal pathogen. We previously identified the presence of cell-associated phytase activity in C. albicans. Here, we reveal for the first time, that orf19.3727 contributes to phytase activity in C. albicans and ultimately to its virulence potency. Compared with its wild type counterpart, disruption of C. albicans orf19.3727 led to decreased phytase activity, reduced ability to form hyphae, attenuated in vitro adhesion, and reduced ability to penetrate human epithelium, which are the major virulence attributes of this yeast. Thus, orf19.3727 of C. albicans plays a key role in fungal pathogenesis. Further, our data uncover a putative novel strategy for anti-Candidal drug design through inhibition of phytase activity of this common pathogen.

Indexed as

6-PhytaseCandida albicansOpen Reading FramesVirulence6-Phytase

Identifiers

PMID29216308
PMCPMC5720748
OpenAlexW2772841280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.