ArticlePloS one2017
Associations of changes in body mass index with all-cause and cardiovascular mortality in healthy middle-aged adults.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Weight variability and cardiovascular outcomes: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- The association between weight fluctuation and all-cause mortality: A systematic review and meta-analysis.Medicine · 2019Pooled it
- BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study.Cardiovascular diabetology · 2024Observational
- Gender differences in midlife to later-life cumulative burden and variability of obesity measures and risk of all-cause and cause-specific mortality.International journal of obesity (2005) · 2024Article
- Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes.JAMA network open · 2024Article
- Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level.Scientific reports · 2022Article
- The association between diabetes and hypertension with the number and extent of weight cycles determined from 6 million participants.Scientific reports · 2022Article
- Influence of changes in body fat on clinical outcomes in a general population: a 12-year follow-up report on the Ansan-Ansung cohort in the Korean Genome Environment Study.Annals of medicine · 2021Article
- Predictors of change in BMI over 10 years among midlife and older adults: Associations with gender, CVD risk status, depressive symptoms, and social support.Social science & medicine (1982) · 2021Article
- Effects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics.BMJ open diabetes research & care · 2020Article
- Magnitude of Central Obesity and its Associated Factors Among Adults in Urban Areas of Northwest Ethiopia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Impact of weight variability on mortality among Korean men and women: a population based study.Scientific reports · 2019Article
- Long-term changes in body weight and physical activity in relation to all-cause and cardiovascular mortality: the HUNT study.The international journal of behavioral nutrition and physical activity · 2019Article
- Associations of variability in body mass index with cardiovascular outcomes in the general population: A systematic review.JRSM cardiovascular diseaseReview
Corrections and comments
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConflicting data exist regarding the association of body mass index (BMI) changes with all-cause and cardiovascular (CV) mortality. The current study investigated the association between changes in BMI and all-cause, CV, and non-CV mortality in a large cohort of middle-aged adults.
methodsA total of 379,535 adults over 40 years of age without pre-existing CV disease or cancer at baseline were enrolled to undergo a series of at least three health examinations of biennial intervals. Changes in BMI between baseline, midpoint follow-up, and final health examination during mean 9.3 years were defined according to the pattern of BMI change as follows: stable, sustained gain, sustained loss, and fluctuation. The relationship between BMI change category and mortality was assessed by multivariate Cox regression reporting hazard ratio (HR) with 95% confidence interval (95% CI).
resultsDuring a mean follow-up of 10.7 years for mortality, 12,378 deaths occurred from all causes, of which 2,114 were CV and 10,264 were non-CV deaths. Sustained BMI gain was associated with the lower risk of all-cause (HR 0.89, 95% CI: 0.83-0.95), CV (HR 0.84, 95% CI 0.72-0.98), and non-CV mortality (HR 0.90, 95% CI 0.84-0.96) compared with stable BMI. Conversely, sustained BMI loss (HR 1.25, 95% CI 1.19-1.32) and fluctuation (HR 1.13, 95% CI 1.08-1.19) displayed a higher risk of all-cause mortality compared with stable BMI, which was mainly attributable to the increase in non-CV mortality.
conclusionSustained BMI gains were associated with reduced risk of all-cause, CV, and non-CV mortality in middle-aged healthy adults.
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