ArticlePloS one2017
Functional lung MRI for regional monitoring of patients with cystic fibrosis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Longitudinal relaxation rate (Magma (New York, N.Y.) · 2025Pooled it
- Non-contrast enhanced functional lung MRI in children: systematic review.Frontiers in pediatrics · 2025Pooled it
- The effectiveness of a mobile high-frequency chest wall oscillation (HFCWO) device for airway clearance.Pediatric pulmonology · 2020Trial
- [Pulmonary imaging of cystic fibrosis with a focus on children and adolescents].Radiologie (Heidelberg, Germany) · 2025Review
- An automated pipeline for computation and analysis of functional ventilation and perfusion lung MRI with matrix pencil decomposition: TrueLung.Zeitschrift fur medizinische Physik · 2025Article
- MRI and Pulmonary Function Tests' Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis.Journal of clinical medicine · 2023Article
- Association of x-ray velocimetry (XV) ventilation analysis compared to spirometry.Frontiers in medical technology · 2023Article
- MRI lung lobe segmentation in pediatric cystic fibrosis patients using a recurrent neural network trained with publicly accessible CT datasets.Magnetic resonance in medicine · 2022Article
- Feasibility of flow-related enhancement brain perfusion MRI.PloS one · 2022Article
- Review
- The Value of PETRA in Pulmonary Nodules of <3 cm Among Patients With Lung Cancer.Frontiers in oncology · 2021Article
- Novel Thoracic MRI Approaches for the Assessment of Pulmonary Physiology and Inflammation.Advances in experimental medicine and biology · 2021Article
- The current status and further prospects for lung magnetic resonance imaging in pediatric radiology.Pediatric radiology · 2020Review
- Ten years of chest MRI for patients with cystic fibrosis : Translation from the bench to clinical routine.Der Radiologe · 2019Review
- Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface.Clinical microbiology reviews · 2019Review
- Three-dimensional Isotropic Functional Imaging of Cystic Fibrosis Using Oxygen-enhanced MRI: Comparison with HyperpolarizedRadiology · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests. MATERIALS AND
methodsSixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment. MRI-derived oxygen enhanced T1 relaxation measurements, fractional ventilation, first-pass perfusion parameters and a morpho-functional CF-MRI score were acquired.
resultsCompared to healthy controls functional lung MRI detected and quantified significantly increased ventilation heterogeneity in CF patients. Regional functional lung MRI measures of ventilation and perfusion as well as the CF-MRI score and pulmonary function tests could not detect a significant treatment effect two hours after a single treatment with hypertonic saline in young adults with CF (p>0.05).
conclusionThis study shows the feasibility of functional lung MRI as a non-invasive, radiation-free tool for monitoring patients with CF.
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