Evidence map›Paper›PMID 29215813›Full record

ArticleJournal of Korean medical science2018

Kidney Transplantation in Patients with Atypical Hemolytic Uremic Syndrome due to Complement Factor H Deficiency: Impact of Liver Transplantation.

Sejin Kim, Eujin Park, Sang Il Min, Nam Joon Yi, Jongwon Ha, Il Soo Ha, Hae Il Cheong, Hee Gyung Kang

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sejin Kim *Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8721-0697
Eujin Park *Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4413-468X
Sang Il MinDepartment of Surgery, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0688-0278
Nam Joon YiDepartment of Surgery, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5467-425X
Jongwon HaDepartment of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Il Soo HaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5428-6209
Hae Il CheongDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7556-1265
Hee Gyung KangDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8323-5320
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtypical hemolytic uremic syndrome (aHUS) is a rare disease that is often associated with genetic defects. Mutations of complement factor H (CFH) are the most common genetic defects that cause aHUS and often result in end-stage renal disease. Since CFH is mainly produced in the liver, liver transplantation (LT) has been performed in patients with defective CFH.

methodsThe clinical courses of four kidney allograft recipients who lost their native kidney functions due to aHUS associated with a CFH mutation were reviewed.

resultsSubject A underwent kidney transplantation (KT) twice, aHUS recurred and the allograft kidney failed within a few years. Subject B received a KT and soon experienced a recurrence of aHUS coinciding with infection. Her allograft kidney function has worsened, and she remains on plasma infusion therapy. Subject C underwent LT followed by KT. She is doing well without plasma infusion therapy after combined LT-KT for 3 years. Subject D received KT following LT and is now recurrence-free from aHUS.

conclusionIn patients with aHUS associated with a CFH mutation, KT without LT was complicated with a recurrence of aHUS, which might lead to allograft loss. Conversely, LT was successful in preventing the recurrence of aHUS and thus might be another option for a recurrence-free life for aHUS patients associated with CFH mutation.

Indexed as

AdolescentAtypical Hemolytic Uremic SyndromeChildComplement Factor HCreatinineDNA Mutational AnalysisFemaleHumansKidney Failure, ChronicKidney TransplantationLiver TransplantationMalePlatelet-Rich PlasmaPolymorphism, Single NucleotideProtein BindingTransplantation, HomologousCFH protein, humanComplement Factor HCreatinineAtypical Hemolytic Uremic SyndromeComplement Factor H, Kidney TransplantationLiver Transplantation

Identifiers

PMID29215813
PMCPMC5729639
OpenAlexW2770902806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.