Evidence map›Paper›PMID 29215787›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2018

Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.

Kyung Nim Noh, Sung Il Park, Raza Qazi, Zhanan Zou, Aaron D Mickle, Jose G Grajales-Reyes, Kyung-In Jang, Robert W Gereau, Jianliang Xiao, John A Rogers and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Semi-Implantable Bioelectronics.Nano-micro letters · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyung Nim NohDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Sung Il ParkDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, USA.
Raza QaziDepartment of Electrical, Computer, and Energy Engineering, University of Colorado Boulder, Boulder, CO, 80309, USA.
Zhanan ZouDepartment of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, 80309, USA.
Aaron D MickleDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, 63130, USA.
Jose G Grajales-ReyesDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, 63130, USA.
Kyung-In JangDepartment of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.
Robert W GereauDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, 63130, USA.
Jianliang XiaoDepartment of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, 80309, USA.
John A RogersDepartment of Materials Science and Engineering, Biomedical Engineering, Neurological Surgery, Chemistry, Mechanical Engineering, Electrical and Computer Science, Northwestern University, Evanston, IL, 60208, USA.
Jae-Woong JeongDepartment of Electrical, Computer, and Energy Engineering, University of Colorado Boulder, Boulder, CO, 80309, USA.ORCID 0000-0001-7607-5453

Funding

Multimodal biocompatible microLED devices for diverse neuroscience applicationsR01NS081707 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W, ROGERS, JOHN · 2012 to 2016
$3.9M
Closed Loop Wireless Monitoring and Optogenetic Modulation of Bladder FunctionF32DK115122 · NIDDK · WASHINGTON UNIVERSITY · PI MICKLE, AARON DAVID · 2017 to 2018
$118k
GENETIC DISSECTION OF BRAINSTEM CIRCUITS AND THEIR ROLE IN PERSISTENT INFLAMMATORY PAINF31NS103472 · NINDS · WASHINGTON UNIVERSITY · PI GRAJALES REYES, JOSE G · 2017 to 2019
$61k
NIDDK NIH HHS F32 DK115122NINDS NIH HHS F31 NS103472NINDS NIH HHS R01 NS081707
6 · The paper itself

Abstract

Combination of optogenetics and pharmacology represents a unique approach to dissect neural circuitry with high specificity and versatility. However, conventional tools available to perform these experiments, such as optical fibers and metal cannula, are limited due to their tethered operation and lack of biomechanical compatibility. To address these issues, a miniaturized, battery-free, soft optofluidic system that can provide wireless drug delivery and optical stimulation for spatiotemporal control of the targeted neural circuit in freely behaving animals is reported. The device integrates microscale inorganic light-emitting diodes and microfluidic drug delivery systems with a tiny stretchable multichannel radiofrequency antenna, which not only eliminates the need for bulky batteries but also offers fully wireless, independent control of light and fluid delivery. This design enables a miniature (125 mm

Indexed as

Wireless TechnologyOptogeneticsPharmacologybattery-freefully implantableneuraloptofluidicwireless

Identifiers

PMID29215787
PMCPMC5912318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.