Evidence map›Paper›PMID 29215456›Full record

ArticlePsychosomatic medicine

Child and Adult Socioeconomic Status and the Cortisol Response to Acute Stress: Evidence From the Multi-Ethnic Study of Atherosclerosis.

Félice Lê-Scherban, Allison B Brenner, Margaret T Hicken, Belinda L Needham, Teresa Seeman, Richard P Sloan, Xu Wang, Ana V Diez Roux

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Félice Lê-ScherbanFrom the Department of Epidemiology and Biostatistics (Lê-Scherban, Wang, Diez Roux), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Institute for Social Research (Brenner, Hicken), University of Michigan, Ann Arbor, MI; Department of Psychiatry (Sloan), Columbia University Medical Center, New York, NY; Department of Epidemiology (Needham), University of Michigan, Ann Arbor, MI; and Department of Geriatrics (Seeman), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Allison B Brenner
Margaret T Hicken
Belinda L Needham
Teresa Seeman
Richard P Sloan
Xu Wang
Ana V Diez Roux
University of California, Los Angeles · US

Funding

Social-biological predictors of heterogeneity in CVD risk in African AmericansP60MD002249 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA, MENDES DE LEON, CARLOS F. · 2007 to 2016
$15.0M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Scientific/Technical CoreP2CHD041028 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brady T West · 2017 to 2026
$6.5M
Stress, Gene-Environment Interaction and Cardiovascular DiseaseR01HL101161 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA, NEEDHAM, BELINDA L. · 2010 to 2013
$4.1M
Socioeconimic Patterning of Inflammation and HemostasisR01HL076831 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ-ROUX, ANA V. · 2004 to 2007
$2.5M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
Tools for Measuring and Analyzing Cortisol Levels in Population Studies of HealthR21DA024273 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA · 2007 to 2010
$1.2M
The Interactive Roles of Neighborhood Characteristics and Genetic Risk in Racial Inequalities in CKDK01DK106322 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2016 to 2020
$819k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
NHLBI NIH HHS F32 HL010161NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL076831NHLBI NIH HHS R01 HL101161NIA NIH HHS P30 AG028748NICHD NIH HHS P2C HD041028NIDA NIH HHS R21 DA024273NIDDK NIH HHS K01 DK106322NIMHD NIH HHS P60 MD002249
6 · The paper itself

Abstract

objectiveA long-hypothesized pathway through which low socioeconomic status (SES) harms health is through dysregulation of the physiologic stress response systems. No previous studies have tested this hypothesis by investigating cortisol reactivity and recovery to acute stress in relation to SES at different times in the life course in adults. Alteration of the cortisol response to an acute stressor could signal dysregulation of the hypothalamic-pituitary-adrenal axis and has been associated with chronic illness.

methodsWe used data on 997 adults 54 years or older from a multiethnic, multisite United States study to examine associations between life course SES and cortisol response to a laboratory stress challenge. Informed by life course theory, we hypothesized that lower child and adult SES would be associated with lower reactivity (i.e., smaller increase in cortisol) and a slower recovery rate (i.e., slower rate of decline in cortisol after the challenge).

resultsIn demographics-adjusted multilevel piecewise linear regression models, low child and adult SES were associated with a 19% (95% CI = 4%-50%) and 27% (7%-55%) slower recovery rate compared with high child and adult SES, respectively. Compared with participants with stable high SES, those with stable low SES had a 48% (16%-70%) slower recovery rate. Differences in reactivity by SES were small.

conclusionsOur results support the hypothesis that low SES throughout life affects the hypothalamic-pituitary-adrenal axis and in turn the ability to recover from exposure to acute stressors. This mechanism can help explain how socioeconomic disparities contribute to disparities in chronic disease.

Indexed as

Adult Survivors of Child Adverse EventsAgedAtherosclerosisFemaleHumansHydrocortisoneMaleMiddle AgedSalivaSocial ClassStress, PsychologicalUnited StatesHydrocortisone

Identifiers

PMID29215456
PMCPMC5794563
OpenAlexW2775476214

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.