ReviewACS combinatorial science2018
Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.
Review in ACS combinatorial science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Catalyzed syntheses of novel series of spiro thiazolidinone derivatives with nano FeScientific reports · 2024Article
- One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles.ACS combinatorial science · 2019Article
- Tetrazoles via Multicomponent Reactions.Chemical reviews · 2019Review
- Selectivity in multiple multicomponent reactions: types and synthetic applications.Beilstein journal of organic chemistry · 2019Review
- Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions.Beilstein journal of organic chemistry · 2019Review
- A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-RSC advances · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
α-Aminomethyl tetrazoles, recently made accessible by an Ugi multicomponent reaction (MCR), were shown to be excellent starting materials for a further Ugi MCR, yielding substituted N-methyl-2-(((1-methyl-1H-tetrazol-5-yl)methyl)amino)acetamides having four points of diversity in a library-to-library approach. The scope and limitations of the two-step sequence was explored by conducting more than 50 reactions. Irrespective of electron-rich and electron-deficient oxo-components and the nature of the isocyanide component, the reactions give excellent yields. Sterically less hindered α-aminomethyl tetrazoles give better yields of in further Ugi MCR. The target scaffold has four points of diversity and is finding applications to fill screening decks for high-throughput screening (HTS) in the European Lead Factory and in structure-based drug design.
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Registered trials
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