ArticleMicrobial biotechnology2018
Citrate, low pH and amino acid limitation induce citrate utilization in Lactococcus lactis biovar diacetylactis.
Article in Microbial biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 41 citations in OpenAlex.
- Comparative genomics and methylome profiling ofMicrobial genomics · 2026Article
- Proteomic Analysis of Lactococcus lactis FM03 Under Prolonged Alkaline Stress.Environmental microbiology · 2026Article
- Optimization of fermentation medium for advancing postbiotic antibacterial activity.AMB Express · 2026Article
- Alkaline pH-Driven Metabolic Plasticity of Lactococcus lactis FM03.Environmental microbiology · 2025Article
- Identification of the global regulatory roles of RraA via the integrative transcriptome and proteome inmSphere · 2024Article
- Potential of Cheese-Associated Lactic Acid Bacteria to Metabolize Citrate and Produce Organic Acids and Acetoin.Metabolites · 2023Article
- Isolation ofMolecules (Basel, Switzerland) · 2023Article
- Microaerobic metabolism of lactate and propionate enhances vitamin BMicrobial cell factories · 2022Article
- A comparative whole-genome approach identifies bacterial traits for marine microbial interactions.Communications biology · 2022Article
- Nitrogenous Compound Utilization and Production of Volatile Organic Compounds among Commercial Wine Yeasts Highlight Strain-Specific Metabolic Diversity.Microbiology spectrum · 2021Article
- Propionibacterium freudenreichii thrives in microaerobic conditions by complete oxidation of lactate to COEnvironmental microbiology · 2021Article
- Article
- Application of a partial cell recycling chemostat for continuous production of aroma compounds at near-zero growth rates.BMC research notes · 2019Article
- TheFrontiers in microbiology · 2019Article
- Large plasmidome of dairy Lactococcus lactis subsp. lactis biovar diacetylactis FM03P encodes technological functions and appears highly unstable.BMC genomics · 2018Article
- Aroma formation during cheese ripening is best resembled by Lactococcus lactis retentostat cultures.Microbial cell factories · 2018Article
- Dynamics in Copy Numbers of Five Plasmids of a Dairy Lactococcus lactis Strain under Dairy-Related Conditions Including Near-Zero Growth Rates.Applied and environmental microbiology · 2018Article
- Citrate, low pH and amino acid limitation induce citrate utilization in Lactococcus lactis biovar diacetylactis.Microbial biotechnology · 2018Article
- Comprehensive Characterization of Five Lactococcus Strains: From Phenotypic Traits to Genomic Features.Acta naturaeArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In Lactococcus lactis subsp. lactis biovar diacetylactis, citrate transport is facilitated by the plasmid-encoded citrate permease (CitP). In this work, we analysed regulation of citrate utilization by pH, nutrient limitation and the presence of citrate at four different levels: (i) plasmid copy number, (ii) citP transcription, (iii) citP mRNA processing and (iv) citrate utilization capacity. Citrate was supplied as cosubstrate together with lactose. The citP gene is known to be induced in cells grown at low pH. However, we demonstrated that transcription of citP was even higher in the presence of citrate (3.8-fold compared with 2.0-fold). The effect of citrate has been overlooked by other researchers because they determined the effect of citrate using M17 medium, which already contains 0.80 ± 0.07 mM citrate. The plasmid copy number increased in cells grown under amino acid limitation (1.6-fold) and/or at low pH (1.4-fold). No significant differences in citP mRNA processing were found. Citrate utilization rates increased from approximately 1 to 65 μmol min
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