ArticleScientific reports2017
Lactation has persistent effects on a mother's metabolism and mitochondrial function.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Breastfeeding shapes a unique tumor-immune landscape in pregnancy-associated breast cancer from GEICAM-EMBARCAM study.Breast cancer research : BCR · 2026Article
- Innovative mitochondria-based holistic 3PM approach to female health status: Facts and outlook.The EPMA journal · 2026Article
- Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress viaMaterials today. Bio · 2025Article
- Recent advances in alcohol metabolism: from the gut to the brain.Physiological reviews · 2025Review
- Assessment of Oxidative Stress and Biometric Data in a Captive Colony of Hamadryas Baboons (Veterinary sciences · 2025Article
- Assessment of per- and polyfluoroalkyl substances (PFAS) exposure and associations with oxidative stress biomarkers among pregnant women from the PROTECT cohort.The Science of the total environment · 2025Article
- Comparison Between SGLT2 Inhibitors and Lactation: Implications for Cardiometabolic Health in Parous Women.Metabolic syndrome and related disorders · 2025Review
- Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model.npj women's health · 2025Article
- Immune Cell Contribution to Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2024Review
- Spatial control of perilacunar canalicular remodeling during lactation.Scientific reports · 2024Article
- Article
- Influence of Breastfeeding on the State of Meta-Inflammation in Obesity-A Narrative Review.Current issues in molecular biology · 2023Review
- Effects of pregnancy and lactation on muscle-tendon morphology.Journal of anatomy · 2023Article
- Cardiometabolic effects of breastfeeding on infants of diabetic mothers.World journal of diabetes · 2023Article
- Article
- Obesity, not a high fat, high sucrose diet alone, induced glucose intolerance and cardiac dysfunction during pregnancy and postpartum.Scientific reports · 2021Article
- Short and long-term effect of reproduction on mitochondrial dynamics and autophagy in rats.Heliyon · 2021Article
- Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats.Physiological reports · 2018Article
- Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes.Nutrients · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Human epidemiological data show that breastfeeding reduces the prevalence of numerous diseases compared to mothers that give birth but do not participate in lactation. The goal of this study was to determine if differences in metabolism, mitochondrial function, and oxidative stress underlie the protective phenotype found in lactating women. Ten-week old female Sprague-Dawley rats were divided into three groups (n = 8 per group): 1) rats that did not reproduce (NR), 2) rats that were allowed to mate and become pregnant but did not suckle their pups after giving birth (NL), and 3) rats that were allowed to mate and become pregnant and suckled their pups for 21 days before weaning (L). All animals were sacrificed at approximately 7 months of age, a time corresponding to 15 weeks after the NL and L females gave birth. Liver mitochondrial respiration was higher in L rats when using NADH-linked substrates and these rats had lower serum glucose concentration. Additionally, the L group exhibited changes in liver, skeletal muscle, and white adipose tissue PPARδ protein levels that may, in part, explain the observed lower serum glucose concentration. These novel animal findings provide evidence of differences in metabolic processes that persist months after weaning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.