Evidence map›Paper›PMID 29214999›Full record

ArticleScientific reports2017

Engineering an aldehyde dehydrogenase toward its substrates, 3-hydroxypropanal and NAD

Ye Seop Park, Un Jong Choi, Nguyen Hoai Nam, Sang Jin Choi, Abdul Nasir, Sun-Gu Lee, Kyung Jin Kim, Gyoo Yeol Jung, Sangdun Choi, Jeung Yeop Shim and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Progress in 1,3-propanediol biosynthesis.Frontiers in bioengineering and biotechnology · 2024
    Review
  6. Structure Based Protein Engineering of Aldehyde Dehydrogenase fromJournal of microbiology and biotechnology · 2022
    Article
  7. Review
  8. Article
  9. Recent Progress in the Understanding and Engineering of Coenzyme BFrontiers in bioengineering and biotechnology · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Ye Seop ParkDepartment of Molecular Science and Technology, Ajou University, 206 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Un Jong ChoiDepartment of Molecular Science and Technology, Ajou University, 206 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Nguyen Hoai NamSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Korea.
Sang Jin ChoiDepartment of Molecular Science and Technology, Ajou University, 206 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Abdul NasirDepartment of Molecular Science and Technology, Ajou University, 206 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.ORCID 0000-0002-2339-3500
Sun-Gu LeeDepartment of Chemical and Biomolecular Engineering, Pusan National University, Pusan, 46241, Korea.
Kyung Jin KimSchool of Life Sciences, Kyungpook National University, Daegu, 41566, Korea.
Gyoo Yeol JungDepartment of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673, Korea.
Sangdun ChoiDepartment of Molecular Science and Technology, Ajou University, 206 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
Jeung Yeop ShimBio R&D Center, Noroo Holdings Co., Ltd, Suwon, 16229, Korea.
Sunghoon ParkSchool of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Korea. parksh@unist.ac.kr.
Tae Hyeon YooDepartment of Molecular Science and Technology, Ajou University, 206 World cup-ro, Yeongtong-gu, Suwon, 16499, Korea. taehyeonyoo@ajou.ac.kr.
Ajou University · KRUlsan National Institute of Science and Technology · KRDaewoo Pharma (South Korea) · KRKyungpook National University · KRPohang University of Science and Technology · KRPusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-Hydroxypropionic acid (3-HP) can be produced via the biological route involving two enzymatic reactions: dehydration of glycerol to 3-hydroxypropanal (3-HPA) and then oxidation to 3-HP. However, commercial production of 3-HP using recombinant microorganisms has been hampered with several problems, some of which are associated with the toxicity of 3-HPA and the efficiency of NAD

Indexed as

Aldehyde OxidoreductasesAzospirillum brasilenseBacterial ProteinsGlyceraldehydeGlycerolLactic AcidNADPropaneProtein ConformationProtein EngineeringSubstrate Specificity2,5-dioxovalerate dehydrogenase3-hydroxypropionaldehydeAldehyde OxidoreductasesBacterial ProteinsGlyceraldehydeGlycerolhydracrylic acidLactic AcidNADPropane

Identifiers

PMID29214999
PMCPMC5719400
OpenAlexW2771079902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.