Evidence map›Paper›PMID 29214998›Full record

ArticleScientific reports2017

Structural insights into the potency of SK channel positive modulators.

Young-Woo Nam, Razan Orfali, Tingting Liu, Kunqian Yu, Meng Cui, Heike Wulff, Miao Zhang

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. KJournal of neuroscience research · 2023
    Review
  7. KBiomedicines · 2023
    Review
  8. Article
  9. Spike Afterhyperpolarizations Govern Persistent Firing Dynamics in Rat Neocortical and Hippocampal Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Atomistic Insights of Calmodulin Gating of Complete Ion Channels.International journal of molecular sciences · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Physiological Roles and Therapeutic Potential of CaFrontiers in molecular neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Young-Woo NamDepartment of Biomedical and Pharmaceutical Sciences & Structural Biology Research Center, Chapman University School of Pharmacy, Irvine, CA, 92618, USA.
Razan OrfaliDepartment of Biomedical and Pharmaceutical Sciences & Structural Biology Research Center, Chapman University School of Pharmacy, Irvine, CA, 92618, USA.
Tingting LiuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Kunqian YuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Meng CuiDepartment of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, MA, 02115, USA.
Heike WulffDepartment of Pharmacology, School of Medicine, University of California, Davis, CA, 95616, USA.
Miao ZhangDepartment of Biomedical and Pharmaceutical Sciences & Structural Biology Research Center, Chapman University School of Pharmacy, Irvine, CA, 92618, USA. zhang@chapman.edu.

Funding

Structure Assisted Design of SK Channel Selective ActivatorsR21NS101876 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WULFF, HEIKE · 2017 to 2018
$410k
Development of SK channel modulators as therapeutic agents for ataxiaR21NS101182 · NINDS · CHAPMAN UNIVERSITY · PI BEZPROZVANNY, ILYA B, ZHANG, MIAO · 2018 to 2019
$356k
NINDS NIH HHS R21 NS101182NINDS NIH HHS R21 NS101876
6 · The paper itself

Abstract

Small-conductance Ca

Indexed as

BenzimidazolesBinding SitesCrystallography, X-RayHumansIndolesOximesSmall-Conductance Calcium-Activated Potassium Channels1-ethyl-2-benzimidazolinone6,7-dichloro-1H-indole-2,3-dione 3-oximeBenzimidazolesIndolesKCNN2 protein, humanOximesSmall-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID29214998
PMCPMC5719431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.