Evidence map›Paper›PMID 29214845›Full record

ArticleAIDS research and human retroviruses2018

High HIV-1 RNA Among Newly Diagnosed People in Botswana.

Vladimir Novitsky, Melanie Prague, Sikhulile Moyo, Tendani Gaolathe, Mompati Mmalane, Etienne Kadima Yankinda, Unoda Chakalisa, Refeletswe Lebelonyane, Nealia Khan, Kathleen M Powis and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01965470 (Botswana Combination Prevention Project), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01965470 phase4completednot on this map

Botswana Combination Prevention Project: -Evaluation Protocol (Protocol #1): Research Design and Impact Evaluation -Closed Clinical Cohort Protocol (Protocol #3) Implementation, Monitoring and Evaluation of Combination HIV Prevention Interventions in Rural and Peri-Urban Communities in Botswana

TypeinterventionalSponsorCenters for Disease Control and PreventionRan2013 to 2018ConditionsHIVArmsCombination Prevention, Enhanced Care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Vladimir Novitsky1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Melanie Prague3 Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
Sikhulile Moyo1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Tendani Gaolathe1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Mompati Mmalane1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Etienne Kadima Yankinda1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Unoda Chakalisa1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Refeletswe Lebelonyane6 Ministry of Health , Republic of Botswana, Gaborone, Botswana .
Nealia Khan2 Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
Kathleen M Powis1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Erik Widenfelt1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Simani Gaseitsiwe1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Scott L Dryden-Peterson1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Molly Pretorius Holme1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Victor De Gruttola3 Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, Massachusetts.
Pam Bachanas9 Division of Global HIV and TB, Centers for Disease Control and Prevention , Atlanta, Georgia .
Joseph Makhema1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
Shahin Lockman1 Botswana Harvard AIDS Institute , Gaborone, Botswana .
M Essex1 Botswana Harvard AIDS Institute , Gaborone, Botswana .

Funding

CGH CDC HHS U2G GH001911PEPFAR
6 · The paper itself

Abstract

HIV-1 RNA level is strongly associated with HIV transmission risk. We sought to determine whether HIV-1 RNA level was associated with prior knowledge of HIV status among treatment-naive HIV-infected individuals in Botswana, a country with high rates of antiretroviral treatment (ART) coverage. This information may be helpful in targeting HIV diagnosis and treatment efforts in similar high HIV prevalence settings in a population-based survey. HIV-infected individuals were identified during a household survey performed in 30 communities across Botswana. ART-naive persons with detectable HIV-1 RNA (>400 copies/mL) were divided into two groups, newly diagnosed and individuals tested in the past who knew about their HIV infection at the time of household visit, but had not taken ART. Levels of HIV-1 RNA were compared between groups, overall and by age and gender. Among 815 HIV-infected ART-naive persons with detectable virus, newly diagnosed individuals had higher levels of HIV-1 RNA (n = 490, median HIV-1 RNA 4.35, interquartile range (IQR) 3.79-4.91 log

Indexed as

AdolescentAdultAnti-HIV AgentsAwarenessBotswanaCD4 Lymphocyte CountCluster AnalysisCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHIV-1HIV InfectionsHumansMaleMass ScreeningMiddle AgedAnti-HIV AgentsRNA, ViralBotswanaHIV-1 RNAHIV transmissionnew HIV diagnosisnewly diagnosed males

Identifiers

PMID29214845
PMCPMC5863222

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