ArticleAnnals of laboratory medicine2018
Prevalence of blaZ Gene and Performance of Phenotypic Tests to Detect Penicillinase in Staphylococcus aureus Isolates from Japan.
Article in Annals of laboratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multi-drug resistant Staphylococcus aureus from Bovine Mastitis: epidemiological and molecular insights from Central Ethiopia.BMC veterinary research · 2026Article
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- The effect of novel β-lactam derivatives synthesized from substituted phenethylamines on resistance genes of MRSA isolates.The Journal of antibiotics · 2024Article
- Study on the Prevalence of Methicillin-ResistantArchives of Razi Institute · 2024Article
- Antimicrobial resistance patterns of Streptococcus uberis isolates from bovine milk in Chiba prefecture, Japan: association between multidrug resistance and clonal complex 996.The Journal of veterinary medical science · 2024Article
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- Bats Are Carriers of Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- First comparative genomic characterization of the MSSA ST398 lineage detected in aquaculture and other reservoirs.Frontiers in microbiology · 2023Article
- Isolation and Determination of Antibacterial Sensitivity Characteristics ofVeterinary medicine international · 2023Article
- Importance of Microbiome of Fecal Samples Obtained from Adolescents with Different Weight Conditions on Resistance Gene Transfer.Microorganisms · 2022Article
- PLSDB: advancing a comprehensive database of bacterial plasmids.Nucleic acids research · 2022Article
- A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.Journal of clinical microbiology · 2021Article
- Emerging of antimicrobial resistance in staphylococci isolated from clinical and food samples in Algeria.BMC research notes · 2018Article
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Authors and funding
6 authors.
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Abstract
Guidelines recommend that clinical laboratories perform phenotypic tests (nitrocefin-based test and penicillin 10-U [P10] or 1-U [P1] zone edge tests) to detect penicillinase in Staphylococcus aureus isolates. This study aimed to assess the prevalence of blaZ encoding penicillinase and perform various phenotypic tests in S. aureus isolates from Japan. We prospectively collected 200 methicillin-susceptible S. aureus isolates from June 2015 to January 2016 and performed six phenotypic tests (nitrocefin-based test, P10 zone edge test/P10 diffusion test, penicillin 2-U [P2] zone edge test/P2 diffusion test, and cloverleaf test) on each sample. We confirmed the presence of blaZ (two blaZ-positive isolates) using PCR. Using blaZ PCR as a standard, we observed a low sensitivity (50%) and positive predictive value (PPV, 50%) of the nitrocefin-based test, low PPV (18.2%) of the P10 zone edge test, low sensitivity (50%) of the P10 diffusion test, low PPV (50% and 22.2%) of the P2 zone edge test and P2 diffusion test, respectively, and low sensitivity (50%) of the cloverleaf test. These data suggest a low performance (sensitivity and PPV) of these six phenotypic tests because of the low prevalence (1%) of blaZ in S. aureus isolates from Japan.
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