ReviewThe Journal of physiology2018
Acute oxygen sensing by the carotid body: a rattlebag of molecular mechanisms.
Review in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis.The Journal of physiology · 2026Review
- The Carotid Body as Part of a Unified Sympathoadrenal System of Neural Crest Derivatives: Insights from Two Centuries of Research.International journal of molecular sciences · 2025Review
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders.The Journal of physiology · 2025Review
- Insights into the control and consequences of breathing adjustments in fishes-from larvae to adults.Frontiers in physiology · 2023Review
- Mechanisms of Chemosensory Transduction in the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- Constitutive Expression of Hif2α Confers Acute OAdvances in experimental medicine and biology · 2023Article
- Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia.Science advances · 2022Article
- Chemoreflex Control as the Cornerstone in Immersion Water Sports: Possible Role on Breath-Hold.Frontiers in physiology · 2022Review
- Acute Oxygen-SensingFrontiers in physiology · 2022Article
- Correlation between convection requirement and carotid body responses to hypoxia and hemoglobin affinity: comparison between two rat strains.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Oxygen-dependent regulation of ion channels: acute responses, post-translational modification, and response to chronic hypoxia.Pflugers Archiv : European journal of physiology · 2021Review
- Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.Physiological reviews · 2021Review
- Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat.Antioxidants (Basel, Switzerland) · 2021Article
- Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α.Frontiers in physiology · 2020Review
- The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system.Cellular and molecular life sciences : CMLS · 2019Review
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- Advances in cellular and integrative control of oxygen and carbon dioxide homeostasis.The Journal of physiology · 2018Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular underpinnings of the oxygen sensitivity of the carotid body Type I cells are becoming better defined as research begins to identify potential interactions between previously separate theories. Nevertheless, the field of oxygen chemoreception still presents the general observer with a bewildering array of potential signalling pathways by which a fall in oxygen levels might initiate Type I cell activation. The purpose of this brief review is to address five of the current oxygen sensing hypotheses: the lactate-Olfr 78 hypothesis of oxygen chemotransduction; the role mitochondrial ATP and metabolism may have in chemotransduction; the AMP-activated protein kinase hypothesis and its current role in oxygen sensing by the carotid body; reactive oxygen species as key transducers in the oxygen sensing cascade; and the mechanisms by which H
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.