Evidence map›Paper›PMID 29214526›Full record

Trial reportJournal of physiology and biochemistry2018

High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals.

Mohammad Reza Izadi, Alireza Ghardashi Afousi, Maryam Asvadi Fard, Mohammad Ali Babaee Bigi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of physiology and biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 13 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 13 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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  6. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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  10. The effects of exercise training on hypertensive older adults: an umbrella meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Mohammad Reza IzadiDepartment of Exercise Physiology, University of Shahid Chamran, Ahvaz, Islamic Republic of Iran.
Alireza Ghardashi AfousiDepartment of Exercise Physiology, University of Tehran, Tehran, Islamic Republic of Iran. Ghardashi.a@ut.ac.ir.
Maryam Asvadi FardDepartment of Medicine, Iran University of Medical Science, Tehran, Islamic Republic of Iran.
Mohammad Ali Babaee BigiCardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Iran University of Medical Sciences · IRShahid Chamran University of Ahvaz · IRShiraz University of Medical Sciences · IRUniversity of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide. Apelin levels and NO bioavailability are impaired in older hypertensive patients. Exercise is an effective intervention for treating hypertension. Our purpose was to evaluate the effect of high-intensity interval training on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals. Thirty treated hypertensive subjects (61.70 ± 5.78 years, 17 males, 13 females) were randomly divided into 6 weeks of high-intensity interval training (n = 15) and control (n = 15). The exercise training was conducted for three 35-min sessions a week (1.5-min interval at 85-90% of heart rate reserve [HRR] and 2 min active phase at 50-55% of HRR). Assessment of plasma apelin, nitrite/nitrate (NOx), and endothelin-1 (ET-1) was performed before and after the intervention. At the end of the study, apelin, and NOx plasma levels increased significantly in the high-intensity interval training (HIIT) group (P = 0.021, P = 0.003, respectively). Conversely, ET-1 plasma levels significantly decreased in the training group after the intervention (P = 0.015). Moreover, there was a positive correlation between the change of plasma apelin and change of plasma NOx (r = 0. 771, P = 0.0008). In addition, there was a negative correlation between the change of plasma ET-1, change of plasma apelin (r = - 0.595, P = 0.019), and variation of NOx (r = - 0.572, P = 0.025). This study indicates that, by increasing of apelin and NOx plasma levels, HIIT may be effective in reducing blood pressure.

Indexed as

AgingHigh-Intensity Interval TrainingAgedAntihypertensive AgentsApelinBiomarkersBlood PressureCombined Modality TherapyFemaleFollow-Up StudiesHeart RateHumansHypertensionLost to Follow-UpMaleMiddle AgedAntihypertensive AgentsApelinBiomarkersNitric OxideApelinEndothelin-1High-intensity interval trainingNOxOlder treated hypertensive

Identifiers

PMID29214526
OpenAlexW2774414950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.