ArticleJournal of microbiology (Seoul, Korea)2017
Effects of dietary poly-β-hydroxybutyrate (PHB) on microbiota composition and the mTOR signaling pathway in the intestines of litopenaeus vannamei.
Article in Journal of microbiology (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 60 citations in OpenAlex.
- Comparative Efficacy of Monobutyrin, Tributyrin, Sodium Butyrate, and Poly-β-hydroxybutyrate on Growth, Intestinal Health, and Nitrite Stress Resistance inAntioxidants (Basel, Switzerland) · 2026Article
- Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut-skin axis.Journal of translational medicine · 2026Review
- Liver Metastatic Breast Cancer: Epidemiology, Dietary Interventions, and Related Metabolism.Nutrients · 2022Review
- Agavin induces beneficial microbes in the shrimp microbiota under farming conditions.Scientific reports · 2022Article
- Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris.Annals of dermatology · 2021Article
- Toxic effects of metal copper stress on immunity, metabolism and pathologic changes in Chinese mitten crab (Eriocheir japonica sinensis).Ecotoxicology (London, England) · 2021Article
- Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei.Fish & shellfish immunology · 2020Article
- Immunomodulatory Role of Microbial Surfactants, with Special Emphasis on Fish.International journal of molecular sciences · 2020Review
- Changes in the microbial community of Litopenaeus vannamei larvae and rearing water during different growth stages after disinfection treatment of hatchery water.Journal of microbiology (Seoul, Korea) · 2020Article
- In vitro human colonic microbiota utilises D-β-hydroxybutyrate to increase butyrogenesis.Scientific reports · 2020Article
- Galactooligosaccharides and Resistant Starch Altered Microbiota and Short-Chain Fatty Acids in anFrontiers in microbiology · 2020Article
- Effect of poly(3-hydroxyalkanoates) as natural polymers on mesenchymal stem cells.World journal of stem cells · 2019Review
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Poly-β-hydroxybutyrate (PHB) is a natural polymer of the short chain fatty acid β-hydroxybutyrate, which acts as a microbial control agent. The mammalian target of the rapamycin (mTOR) signaling pathway plays a crucial role in intestine inflammation and epithelial morphogenesis. In this study, we examined the composition of intestine microbiota, and mTOR signaling-related gene expression in Pacific white shrimp Litopenaeus vannamei fed diets containing different levels of PHB: 0% (Control), 1% (PHB1), 3% (PHB3), and 5% (PHB5) (w/w) for 35 days. High-throughput sequencing analysis revealed that dietary PHB altered the composition and diversity of intestine microbiota, and that the microbiota diversity decreased with the increasing doses of PHB. Specifically, dietary PHB increased the relative abundance of Proteobacteria and Tenericutes in the PHB1 and PHB5 groups, respectively, and increased that of Gammaproteobacteria in the three PHB groups. Alternatively, PHB decreased Alphaproteobacteria in the PHB3 and PHB5 groups. At the genus level, dietary PHB increased the abundance of beneficial bacteria, such as Bacillus, Lactobacillus, Lactococcus, Clostridium, and Bdellovibrio. The relative mRNA expression levels of the mTOR signaling-related genes TOR, 4E-BP, eIF4E1α, and eIF4E2 all increased in the three PHB treatment groups. These results revealed that dietary PHB supplementation had a beneficial effect on intestine health of L. vannamei by modulating the composition of intestine microbiota and activating mTOR signaling.
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