Evidence map›Paper›PMID 29214443›Full record

Observational studyPediatric nephrology (Berlin, Germany)2018

Contribution of symmetric dimethylarginine to GFR decline in pediatric chronic kidney disease.

Ellen R Brooks, Shannon Haymond, Alfred Rademaker, Christopher Pierce, Irene Helenowski, Rod Passman, Faye Vicente, Bradley A Warady, Susan L Furth, Craig B Langman

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00327860 recruitingnot on this map

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2003 to 2028Enrolled1,300ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ellen R BrooksFeinberg School of Medicine, Northwestern University, Chicago, IL, USA. e-brooks3@northwestern.edu.ORCID 0000-0003-3468-8117
Shannon HaymondFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Alfred RademakerFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Christopher PierceDepartment of Epidemiology, University Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Irene HelenowskiFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Rod PassmanFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Faye VicenteDepartment of Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Bradley A WaradyDivision of Pediatric Nephrology, The Children's Mercy Hospital, Kansas City, MO, USA.
Susan L FurthDivision of Nephrology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Craig B LangmanFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Northwestern University · USChildren's Hospital of Philadelphia · USChildren's Mercy Hospital · USJohns Hopkins University · USLurie Children's Hospital · US

Funding

Prognostic Biomarkers to Predict Progression of Pediatric Chronic Kidney DiseaseR01HD074596 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI BROOKS, ELLEN ROSE · 2013 to 2014
$593k
NICHD NIH HHS R01 HD074596
6 · The paper itself

Abstract

backgroundIn pediatric chronic kidney disease (pCKD), traditional factors (proteinuria, etiology, and race) do not fully explain disease progression. The levels of methylated arginine derivatives (MADs: asymmetric and symmetric dimethylarginine, respectively) rise in CKD and increase with CKD progression. The impact of MADs on glomerular filtration rate (GFR) decline has not been examined in pCKD. The aim of this study was to examine the additive impact of baseline (BL) levels of MADs on directly measured GFR (mGFR) decline per year (ml/min/1.73 m

methodsPlasma and data, including mGFR by plasma iohexol clearance, were provided by the prospective, observational Chronic Kidney Disease in Children study. BL MADs were analyzed by high-performance liquid chromatography-tandem mass spectrometry.

resultsFor 352 pCKD subjects, the median [interquartile range] BL mGFR was 45 [35, 57] ml/min/1.73 m

conclusionsIn pCKD, higher concentrations of BL MADs were inversely related to BL mGFR. MADs did not affect the CKD progression rate. Quantification of this relationship is novel to the pCKD literature.

Indexed as

AdolescentArginineChildChild, PreschoolChromatography, High Pressure LiquidDisease ProgressionFemaleGlomerular Filtration RateHumansInfantKidneyMaleMass SpectrometryProspective StudiesRenal Insufficiency, ChronicArgininesymmetric dimethylarginineChronic kidney diseaseCKD progressionMethylated arginine derivativesPediatricSDMA

Identifiers

PMID29214443
OpenAlexW2773280694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.