Evidence map›Paper›PMID 29214215›Full record

ArticleNPJ breast cancer2017

Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast.

Salvatore Piscuoglio, Charlotte K Y Ng, Felipe C Geyer, Kathleen A Burke, Catherine F Cowell, Luciano G Martelotto, Rachael Natrajan, Tatiana Popova, Christopher A Maher, Raymond S Lim and 6 more

Open access · goldAbstract read
In one paragraph

Article in NPJ breast cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 129 citations in OpenAlex.

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  13. Molecular Basis of Breast Tumor Heterogeneity.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 5 countries.

Salvatore Piscuoglio *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.ORCID 0000-0003-2686-2939
Charlotte K Y Ng *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.ORCID 0000-0002-6100-0026
Felipe C GeyerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Kathleen A BurkeDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Catherine F CowellDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Luciano G MartelottoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Rachael NatrajanThe Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Tatiana PopovaINSERM U934, Institut Curie, Paris, France.
Christopher A MaherMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO USA.
Raymond S LimDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Ino de BruijnDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Odette MarianiINSERM U934, Institut Curie, Paris, France.
Larry NortonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Anne Vincent-SalomonINSERM U934, Institut Curie, Paris, France.
Britta WeigeltDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Jorge S Reis-FilhoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.
Memorial Sloan Kettering Cancer Center · USInserm · FRInstitute of Cancer Research · GBJames S. McDonnell Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal elements. Here we sought to define whether histologically distinct subgroups of MBCs would be underpinned by distinct genomic and/or transcriptomic alterations. Microarray-based copy number profiling identified limited but significant differences between the distinct MBC subtypes studied here, despite the limited sample size (

Identifiers

PMID29214215
PMCPMC5711926
OpenAlexW2768229822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.