Evidence map›Paper›PMID 29214210›Full record

ArticleeNeuro

Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions.

Tristan P Hedrick, William P Nobis, Kendall M Foote, Toshiyuki Ishii, Dane M Chetkovich, Geoffrey T Swanson

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Activation of Extrasynaptic Kainate Receptors Drives Hilar Mossy Cell Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tristan P HedrickDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-9765-9500
William P NobisDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-2318-6077
Kendall M FooteDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-8086-5674
Toshiyuki IshiiDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-5067-1035
Dane M ChetkovichDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Geoffrey T SwansonDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.ORCID 0000-0002-6645-9733

Funding

Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
HCN Channel Trafficking in EpilepsyR01NS059934 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHETKOVICH, DANE M · 2008 to 2017
$3.1M
Discovery of novel small molecule antidepressantsR01MH106511 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHETKOVICH, DANE M, SCHILTZ, GARY E · 2016 to 2018
$1.1M
Characterizing antidepressant-like effects of a novel peptide HCN channel inhibitorR21MH113262 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHETKOVICH, DANE M · 2017 to 2018
$430k
Kainate Receptors in Signaling Between Hippocampal Mossy Cells and Granule CellsR21NS090040 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SWANSON, GEOFFREY T · 2014 to 2015
$425k
NCATS NIH HHS KL2 TR002245NIMH NIH HHS R01 MH106511NIMH NIH HHS R21 MH113262NINDS NIH HHS R01 NS059934NINDS NIH HHS R21 NS090040
6 · The paper itself

Abstract

Hilar mossy cells (HMCs) in the hippocampus receive glutamatergic input from dentate granule cells (DGCs) via mossy fibers (MFs) and back-projections from CA3 pyramidal neuron collateral axons. Many fundamental features of these excitatory synapses have not been characterized in detail despite their potential relevance to hippocampal cognitive processing and epilepsy-induced adaptations in circuit excitability. In this study, we compared pre- and postsynaptic parameters between MF and CA3 inputs to HMCs in young and adult mice of either sex and determined the relative contributions of the respective excitatory inputs during

Indexed as

AnimalsCA3 Region, HippocampalExcitatory Postsynaptic PotentialsFemaleMaleMiceMice, Inbred C57BLMossy Fibers, HippocampalNeural PathwaysNeuronal PlasticityOrgan Culture TechniquesPyramidal CellsSynapsesSynaptic TransmissionagingCA3hilusmossy cellseizure

Identifiers

PMID29214210
PMCPMC5714709

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.