Evidence map›Paper›PMID 29214115›Full record

ArticleACS macro letters2017

Morphology Under Control: Engineering Biodegradable Stomatocytes.

Imke A B Pijpers, Loai K E A Abdelmohsen, David S Williams, Jan C M van Hest

Abstract read
In one paragraph

Article in ACS macro letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
  3. Engineering Motile Coacervate Droplets via Nanomotor Stabilization.Journal of the American Chemical Society · 2025
    Article
  4. Fast and Autonomous Mannosylated Nanomotors for Dynamic Cancer Cell Targeting.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Shape Transformation of Polymer Vesicles.Accounts of materials research · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. ScatteringNanoscale advances · 2021
    Article
  17. Review
  18. Article
  19. Photoactivated Polymersome Nanomotors: Traversing Biological Barriers.Angewandte Chemie (International ed. in English) · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Imke A B PijpersEindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600MB Eindhoven, The Netherlands.
Loai K E A AbdelmohsenEindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600MB Eindhoven, The Netherlands.
David S WilliamsEindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600MB Eindhoven, The Netherlands.
Jan C M van HestEindhoven University of Technology, P.O. Box 513 (STO 3.31), 5600MB Eindhoven, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biodegradable nanoarchitectures, with well-defined morphological features, are of great importance for nanomedical research; however, understanding (and thereby engineering) their formation is a substantial challenge. Herein, we uncover the supramolecular potential of PEG-PDLLA copolymers by exploring the physicochemical determinants that result in the transformation of spherical polymersomes into stomatocytes. To this end, we have engineered blended polymersomes (comprising copolymers with varying lengths of PEG), which undergo solvent-dependent reorganization inducing negative spontaneous membrane curvature. Under conditions of anisotropic solvent composition across the PDLLA membrane, facilitated by the dialysis methodology, we demonstrate osmotically induced stomatocyte formation as a consequence of changes in PEG solvation, inducing negative spontaneous membrane curvature. Controlled formation of unprecedented, biodegradable stomatocytes represents the unification of supramolecular engineering with the theoretical understanding of shape transformation phenomena.

Identifiers

PMID29214115
PMCPMC5708263

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.