Evidence map›Paper›PMID 29214051›Full record

ArticleNPJ aging and mechanisms of disease2017

Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration.

Xinping Chen, Hana Hall, Jeffrey P Simpson, Walter D Leon-Salas, Donald F Ready, Vikki M Weake

Open access · goldAbstract read
In one paragraph

Article in NPJ aging and mechanisms of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 51 citations in OpenAlex.

  1. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  2. Article
  3. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Antioxidants (Basel, Switzerland) · 2024
    Article
  6. Differential regulation of sleep by blue, green, and red light inFrontiers in behavioral neuroscience · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Light modulatesAging · 2023
    Article
  11. OralPharmaceutics · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Regulating Effect of CytochromeMolecules (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xinping ChenDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907 USA.
Hana HallDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907 USA.
Jeffrey P SimpsonDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907 USA.
Walter D Leon-SalasPurdue Polytechnic Institute, Purdue University, West Lafayette, IN 47907 USA.
Donald F ReadyDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907 USA.
Vikki M WeakeDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907 USA.ORCID 0000-0002-5933-9952
Purdue University West Lafayette · USUniversity of Notre Dame · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
CYTOSKELETAL MECHANISMS OF RETINAL DEVELOPMENTR01EY010306 · NEI · PURDUE UNIVERSITY WEST LAFAYETTE · PI READY, DONALD F · 1994 to 2013
$3.5M
Epigenetic Regulation of Gene Expression in the Aging EyeR01EY024905 · NEI · PURDUE UNIVERSITY · PI WEAKE, VIKKI MARIE · 2015 to 2020
$2.3M
Laser Scanning Confocal MicroscopeS10RR023734 · NCRR · PURDUE UNIVERSITY · PI FEKETE, DONNA M · 2010 to 2010
$500k
NCI NIH HHS P30 CA023168NCRR NIH HHS S10 RR023734NEI NIH HHS R01 EY010306NEI NIH HHS R01 EY024905NIH HHS P40 OD018537
6 · The paper itself

Abstract

Lipid peroxides are generated by oxidative stress in cells, and contribute to ageing and neurodegenerative disease. The eye is at special risk for lipid peroxidation because photoreceptors possess amplified sensory membranes rich in peroxidation-susceptible polyunsaturated fatty acids. Light-induced lipid peroxidation in the retina contributes to retinal degeneration, and lipid peroxidation has been implicated in the progression of age-associated ocular diseases such as age-related macular degeneration (AMD). Here, we show that exposing

Identifiers

PMID29214051
PMCPMC5712525
OpenAlexW2770594766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.