ArticleMaternal health, neonatology and perinatology2017
Folic acid level and preterm birth among Sudanese women.
Article in Maternal health, neonatology and perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis.Italian journal of pediatrics · 2020Pooled it
- Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine.Biosensors · 2023Review
- The interaction between no folic acid supplementation during early pregnancy and preeclampsia increased the risk of preterm birth.Saudi medical journal · 2023Article
- Biological Role of Folic Acid in Pregnancy and Possible Therapeutic Application for the Prevention of Preeclampsia.Biomedicines · 2023Review
- Maternal Risk Factors Associated with Preterm Births among Pregnant Women in Mogadishu, Somalia.Children (Basel, Switzerland) · 2022Article
- The association between periconceptional folic acid supplementation and the risk of preterm birth: a population-based retrospective cohort study of 200,000 women in China.European journal of nutrition · 2021Article
- Periconceptional folic acid usage and its associated factors in eastern Sudan: A cross-sectional study.Women's health (London, England)Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm birth (PTB) is the major health problem world-wide; there are few published studies on PTB and folic acid.
methodsThe study was conducted to assess the serum level of folic acid in PTB. A case-control study was conducted at Saad Abualila maternity hospital (Khartoum, Sudan) during the period of March through December 2015. Women who delivered live singleton babies were dived in two groups; the cases were women who had PTB "delivery before completed 37weeks but after 24 weeks of pregnancy" and the controls were women who delivered at term (37-42 weeks). Medical and obstetrics history was gathered using questionnaire. Serum folic acid was measured.
resultsOne hundred and twelve (56 in arm of the study) women were enrolled to the study. There was no significant difference between the cases and the controls in their age, parity, hemoglobin, body mass index, education and occupation. The median (interquartile) level of folic acid was significantly lower in the cases (PTB) than the level in the controls, 4.8(2.8-8.2) vs. 9.5(8.6-12.0) ng/ml. In binary regression, folic acid level was associated with lower risk of PTB (OR=0.64; 95%=0.53-0.77,
conclusionThus serum folic acid level was significantly lower in women with PTB. Folic acid level was associated with lower risk of PTB.
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