Evidence map›Paper›PMID 29214033›Full record

ArticleLupus science & medicine2017

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.

Sasha Bernatsky, Héctor A Velásquez García, John J Spinelli, Patrick Gaffney, Karin E Smedby, Rosalind Ramsey-Goldman, Sophia S Wang, Hans-Olov Adami, Demetrius Albanes, Emanuele Angelucci and 91 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Cancer in connective tissue disease.Frontiers in immunology · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Novel Insights Into the Long-Term Immune Health of Diffuse Large B-Cell Lymphoma Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Article
  9. Article
  10. Article
  11. A review on SLE and malignancy.Best practice & research. Clinical rheumatology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

101 authors at 20 institutions in 14 countries.

Sasha BernatskyDivision of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Héctor A Velásquez GarcíaBC Cancer Research Centre and School of Population and Public Health, University of British Columbia, Vancouver, Canada.
John J SpinelliBC Cancer Research Centre and School of Population and Public Health, University of British Columbia, Vancouver, Canada.
Patrick GaffneyArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Karin E SmedbyClinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, and Hematology Center, Karolinska University Hospital, Stockholm, Sweden.
Rosalind Ramsey-GoldmanFeinberg School of Medicine, Northwestern University, Chicago, USA.
Sophia S WangDivision of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, Duarte, USA.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Emanuele AngelucciHematology Unit, Ospedale Oncologico di Riferimento Regionale 'A. Businco', Cagliari, Italy.
Stephen M AnsellDepartment of Medicine, Mayo Clinic, Rochester, USA.
Yan W AsmannDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, USA.
Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Yolanda BenaventeCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Kimberly A BertrandSlone Epidemiology Center, Boston University, Boston, USA.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
Heiner BoeingDepartment of Epidemiology, German Institute for Human Nutrition, Potsdam, Germany.
Paolo BoffettaThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA.
Paul BrennanInternational Agency for Research on Cancer (IARC), Lyon, France.
Angela R Brooks-WilsonGenome Sciences Centre, BC Cancer Agency, Vancouver, Canada.
James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Jacqueline ClavelEpidemiology of childhood and adolescent cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.
Lucia CondeDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA.
Karen H CotenbaderDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, USA.
David G CoxINSERM U1052, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France.
Wendy CozenDepartment of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, USA.
Simon CrouchDepartment of Health Sciences, University of York, York, UK.
Anneclaire J De RoosDepartment of Environmental and Occupational Health, Dornsife School of Public Health at Drexel University, Philadelphia, USA.
Silvia de SanjoseCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Simonetta Di LolloDepartment of Surgery and Translational Medicine, Section of Anatomo-Pathology, University of Florence, Florence, Italy.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, USA.
Ahmet DoganDepartments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czech Republic.
Hervé GhesquièresDepartment of Hematology, Centre Léon Bérard, Lyon, France.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Thomas M HabermannDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, USA.
Corinne HaiounLymphoid Malignancies Unit, Henri Mondor Hospital and University Paris Est, Créteil, France.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Henrik HjalgrimDivision ofHealth Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Theodore R HolfordDepartment of Biostatistics, Yale School of Public Health, New Haven, USA.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, USA.
Rudolph KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eleanor KaneDepartment of Health Sciences, University of York, York, UK.
Rachel S KellyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
Robert J KleinIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
Anne KrickerSydney School of Public Health, The University of Sydney, Sydney, Australia.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Charles LawrenceWestat Inc, Rockville, USA.
Mark LiebowDepartment of Medicine, Mayo Clinic, Rochester, USA.
Tracy LightfootDepartment of Health Sciences, University of York, York, UK.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, USA.
Marc MaynadieRegistre des Hémopathies Malignes de Côte d'Or, EA 4184, Univ. Bourgogne Franche-Comté and Dijon University Hospital, Dijon, France.
James McKayInternational Agency for Research on Cancer (IARC), Lyon, France.
Mads MelbyeDivision ofHealth Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Thierry J MolinaDepartment of Pathology, AP-HP, Necker Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, France.
Alain MonnereauEpidemiology of childhood and adolescent cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Alexandra NietersCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Anne J NovakDepartment of Medicine, Mayo Clinic, Rochester, USA.
Kenneth OffitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
Mark P PurdueOntario Health Study, Toronto, Canada.
Marco RaisDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Italy.
Jacques RibyDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA.
Eve RomanDepartment of Health Sciences, University of York, York, UK.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Gilles SallesDepartment of Hematology, Hospices Civils de Lyon, Pierre benite Cedex, France.
Gianluca SeveriHuman Genetics Foundation, Turin, Italy.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, USA.
Christine F SkibolaDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA.
Susan L SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, USA.
Alex SmithDepartment of Health Sciences, University of York, York, UK.
Martyn T SmithDivision of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, USA.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Australia.
Anthony StainesSchool of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, USA.
Carrie A ThompsonDepartment of Medicine, Mayo Clinic, Rochester, USA.
Hervé TillyCentre Heni Becquerel, Université de Rouen, Rouen, France.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA.
Anne TjonnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Jenny TurnerFaculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
Claire M VajdicCentre for Big Data Research in Health, University of New South Wales, Sydney, Australia.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Joseph VijaiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
Paolo VineisMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Jarmo VirtamoChronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
Thomas E WitzigDepartment of Medicine, Mayo Clinic, Rochester, USA.
Andrew ZelenetzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, USA.
Yawei ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, USA.
Tongzhang ZhengDepartment of Epidemiology, Brown School of Public Health, Providence, USA.
Mariagrazia ZuccaDepartment of Biomedical Science, University of Cagliari, Monserrato, Italy.
Ann E ClarkeDivision of Rheumatology, University of Calgary, Calgary, Canada.
Division of Cancer Epidemiology and GeneticsMayo Clinic · USUniversity of York · GBMemorial Sloan Kettering Cancer Center · USMayo Clinic in Florida · USUniversity of Alabama at Birmingham · USAmerican Cancer Society · USBrigham and Women's Hospital · USCentre de Recherche Épidémiologie et Statistique · FRCentre international de recherche sur le cancer · FRHarvard University · USHeidelberg University · DEIcahn School of Medicine at Mount Sinai · USInstitut d'Investigació Biomédica de Bellvitge · ESStatens Serum Institut · DKUniversity of British Columbia · CAUniversity of Cagliari · ITUniversity of California, San Francisco · USBC Cancer Agency · CABeckman Research Institute

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
TRIGGERING CELL DEATH IN B CELL LYMPHOMAP01CA034233 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 1985 to 2010
$19.5M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
NCATS NIH HHS UL1 TR000135NCCDPHP CDC HHS U58 DP000807NCI NIH HHS K08 CA134919NCI NIH HHS N01 CO012400NCI NIH HHS N01 PC065064NCI NIH HHS N01 PC067008NCI NIH HHS N01 PC067009NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA034233NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA045614NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA062006NCI NIH HHS R01 CA087014NCI NIH HHS R01 CA092153NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA104682NCI NIH HHS R01 CA122663NCI NIH HHS R01 CA134674NCI NIH HHS R01 CA148690NCI NIH HHS R01 CA149445NCI NIH HHS R01 CA154643NCI NIH HHS R03 CA089745NCI NIH HHS R21 CA165923NCI NIH HHS R25 CA098566NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA118444NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG007033NIEHS NIH HHS P30 ES000260NIGMS NIH HHS P30 GM110766World Health Organization 001
6 · The paper itself

Abstract

objectiveDeterminants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.

methodsGWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.

resultsAmong the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.

conclusionsThese data suggest several plausible genetic links between DLBCL and SLE.

Indexed as

lymphomamalignancySystemic lupus

Identifiers

PMID29214033
PMCPMC5715504
OpenAlexW2768240243

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