ArticleDementia & neuropsychologia
Epilepsy in patients with Alzheimer's disease: A systematic review.
Article in Dementia & neuropsychologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The rise and deceleration of neuronal excitability in aging and Alzheimer's disease: Mechanisms, implications, and therapeutic targets.Ageing research reviews · 2026Review
- Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies.Frontiers in neurology · 2024Review
- The bidirectional relationship between Alzheimer's disease (AD) and epilepsy: A Mendelian randomization study.Brain and behavior · 2023Article
- Review
- Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus.Brain research bulletin · 2022Review
- Network Preservation Analysis Reveals Dysregulated Synaptic Modules and Regulatory Hubs Shared Between Alzheimer's Disease and Temporal Lobe Epilepsy.Frontiers in genetics · 2022Article
- Optimal Use of Perampanel in Elderly Asian Patients with Epilepsy: Expert Opinion.Therapeutics and clinical risk management · 2022Article
- A review of the mechanisms underlying selected comorbidities in Alzheimer's disease.Pharmacological reports : PR · 2021Review
- New Insights Into the Anticonvulsant Effects of Essential Oil FromFrontiers in pharmacology · 2021Article
- Analysis of Shared Genetic Regulatory Networks for Alzheimer's Disease and Epilepsy.BioMed research international · 2021Article
- A systematic approach for identifying shared mechanisms in epilepsy and its comorbidities.Database : the journal of biological databases and curation · 2018Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) and epilepsy are common disorders in the elderly. Evidence demonstrates that patients with AD have an increased risk of developing epilepsy and seizures.
objectiveTo review epidemiological, clinical and treatment aspects of epilepsy and AD.
methodsWe reviewed databases (PubMED, LiLACS, Scielo) conducting a search for manuscripts using the terms Alzheimer's disease and epilepsy.
resultsManuscripts related to the areas of interest were reviewed. Studies revealed that epilepsy is more frequent among AD patients. The combined presence of the two disorders may be related to mechanisms of neuronal hyperexcitability as a consequence of amyloid-beta protein (Aβ) or phosphorylated tau accumulation, as well as to structural changes in cortical and hippocampal regions. Available data suggest that the new generation of antiepileptic drugs (AEDs) are better tolerated in the elderly population, and may also be the best option in patients with AD and epilepsy.
conclusionFurther prospective studies involving evaluation of concomitant dementia and epilepsy, neurophysiological findings and biomarkers need to be performed.
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Registered trials
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