Evidence map›Paper›PMID 29213801›Full record

ArticleDementia & neuropsychologia

Systematic review of the literature on vitamin A and memory.

Yara Dadalti Fragoso, Niklas Söderberg Campos, Breno Faria Tenrreiro, Fernanda Jussio Guillen

Open access · diamondAbstract read
In one paragraph

Article in Dementia & neuropsychologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yara Dadalti FragosoHead of the Department of Neurology, Universidade Metropolitana de Santos, SP, Brazil.
Niklas Söderberg CamposMedical Student, Universidade Metropolitana de Santos, SP, Brazil.
Breno Faria TenrreiroMedical Student, Universidade Metropolitana de Santos, SP, Brazil.
Fernanda Jussio GuillenMedical Student, Universidade Metropolitana de Santos, SP, Brazil.
Universidade Metropolitana de Santos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the last 30 years, a variety of studies reporting the effects of vitamin A on memory have been published.

objectiveTo perform a rigorous systematic review of the literature on vitamin A and memory in order to organize evidence-based data on the subject.

methodsFour authors carried out the systematic review in accordance with strict guidelines. The terms "vitamin A" OR "retinol" OR "retinoic acid" AND "memory" OR "cognition" OR "Alzheimer" were searched in virtually all medical research databases.

resultsFrom 236 studies containing the key words, 44 were selected for this review, numbering 10 reviews and 34 original articles. Most studies used animal models for studying vitamin A and cognition. Birds, mice and rats were more frequently employed whereas human studies accounted for only two reports on brain tissue from autopsies and one on the role of isotretinoin in cognition among individuals taking this medication to treat acne.

conclusionVitamin A may be an important and viable complement in the treatment and prevention of Alzheimer's disease. Clinical trials are imperative and, at present, there is no evidence-based data to recommend vitamin A supplementation for the prevention or treatment of Alzheimer's disease.

Indexed as

Alzheimercognitionmemoryretinoic acidretinolvitamin A

Identifiers

PMID29213801
PMCPMC5619333
OpenAlexW2131549252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.