Evidence map›Paper›PMID 29213490›Full record

ArticleDementia & neuropsychologia

Neuropathological findings in entorhinal cortex of subjects aged 50 years or older and their correlation with dementia in a sample from Southern Brazil.

Edson Rodrigues Neto, Mariana K Fonseca, Álvaro C B Guedes, Francine H Oliveira, Arlete Hilbig, Liana Lisboa Fernandez

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia & neuropsychologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Edson Rodrigues NetoMedical Student at the Federal University of Health Sciences of Porto Alegre (UFCSPA). Scientific initiation scholars of the Foundation for Research of Rio Grande do Sul.
Mariana K FonsecaMedical Student at the Federal University of Health Sciences of Porto Alegre (UFCSPA). Scientific initiation scholars of the Foundation for Research of Rio Grande do Sul.
Álvaro C B GuedesMedical Student at the Federal University of Health Sciences of Porto Alegre (UFCSPA). Scientific initiation scholars of the Foundation for Research of Rio Grande do Sul.
Francine H OliveiraPathologist. Specialist in Neuropathology at the Institute of Neuropathology of the University Hospital of Zurich. MSc in Pathology at the Federal University of Health Sciences of Porto Alegre, Porto Alegre RS, Brazil.
Arlete HilbigNeurologist. PhD in Internal Medicine at the Federal University of Rio Grande do Sul, Porto Alegre RS, Brazil. Associate Professor at the Federal University of Health Sciences of Porto Alegre, Porto Alegre RS, Brazil.
Liana Lisboa FernandezNeurologist. PhD in Cellular and Molecular Biology at the Pontifical Catholic University of Rio Grande do Sul, Porto Alegre RS, Brazil and the University of Barcelona, and Adjunct Professor at the Federal University of Health Sciences of Porto Alegre, Porto Alegre RS, Brazil.
Universidade Federal de Ciências da Saúde de Porto Alegre · BRPontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aims of this study were to survey neurodegenerative changes detected by abnormal protein deposits in the Entorhinal Cortex (EC) of subjects aged 50 years or older and to correlate these findings with suspected dementia, as detected by the IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly).

methodsFourteen brains were submitted to the immunohistochemistry technique for different proteins (beta-amyloid, tau, α-synuclein and phospho-TDP-43) and data obtained compared with IQCODE scores.

resultsFifty-seven percent of the individuals exhibited IQCODE results compatible with dementia, being classified into the demented group (DG): 87.5% of patients had neuropathological findings corresponding to Alzheimer's-like brain pathology (ALBP). Of the patients in the non-demented group (NDG), 16.7% met neuropathological criteria for ALBP. All individuals in the DG showed deposits of more than one kind of protein in the EC. The most common association was hyperphosphorylated tau and beta-amyloid protein (87.5%). DISCUSSION: Most individuals with dementia had neuropathological findings of ALBP, as did one individual with no signs of dementia, characterizing a preclinical stage. The results of this study suggest that deposits of a single type of anomalous protein are normal findings in an aging brain, while more than one kind of protein or the combined presence of anomalous protein deposits indicate the presence of dementia.

Indexed as

Alzheimeranomalous protein depositsdementiaentorhinal corteximmunohistochemistryIQCODE

Identifiers

PMID29213490
PMCPMC5619211
OpenAlexW2606973507

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.