Evidence map›Paper›PMID 29213348›Full record

ArticleOxidative medicine and cellular longevity2017

Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation.

Xu Xiao, Huiyuan Hou, Victor Lin, Daisy Ho, Kyle Tran, Briana Che, Adam May, Jiancheng Zhang, Zhigang Lu, Zhongping Lu and 1 more

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Xu XiaoDepartment of Emergency Medicine, Sichuan People's Hospital, Chengdu 610061, China.ORCID 0000-0003-2173-505X
Huiyuan HouDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Victor LinDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Daisy HoDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Kyle TranDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Briana CheDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Adam MayDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Jiancheng ZhangDepartment of Emergency Medicine, Sichuan People's Hospital, Chengdu 610061, China.
Zhigang LuDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.
Zhongping LuDepartment of Ophthalmology, Huaxi Hospital, Chengdu 610061, China.
Peter X ShawDepartment of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-7392-6224
University of California San Diego · USFourth People's Hospital of Sichuan Province · CN

Funding

HTRA1 as a Therapeutic Target in the Treatment of Wet AMDR01EY025693 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAW, PETER X · 2015 to 2019
$1.8M
NEI NIH HHS R01 EY025693
6 · The paper itself

Abstract

objectiveTo investigate the protective effect of probucol on induced cardiac arrest (CA) rats and possible mechanisms.

methodsSprague Dawley rats were orally administrated with probucol at different dosage or vehicle for 5 days and subjected to a CA model by electrical stimulation, followed by cardiopulmonary resuscitation (CPR). The return of spontaneous circulation (ROSC) rate, antioxidant enzyme activities, and lipid oxidation markers were measured in serum and myocardium. Hemodynamic parameters and myocardial functions of animals were analyzed. Expression of erythroid-derived 2-like 2 (NFE2L2) and Kelch-like ECH-associated protein 1 (KEAP1) in the myocardium were examined with immunohistochemistry.

resultsProbucol treatment significantly increased the ROSC rate and survival time of CA-induced rats. After ROSC, levels of oxidation-specific markers were decreased, while activities of antioxidant enzymes were increased significantly in probucol treatment groups. The probucol treatment improves hemodynamic parameters and myocardial functions. These parameter changes were in a dose-dependent manner. In the probucol treatment groups, the expression of KEAP1 was downregulated, while that of NFE2L2 was upregulated significantly.

conclusionIn the CA-induced rat model, probucol dose dependently improved the ROSC rate, prolonged survival time, alleviated oxidative stress, and improved cardiac function. Such protective effects are possibly through regulations of the KEAP1-NFE2L2 system.

Indexed as

AnimalsAntioxidantsCardiopulmonary ResuscitationDisease Models, AnimalGlutathione PeroxidaseHeart ArrestHemodynamicsKaplan-Meier EstimateKelch-Like ECH-Associated Protein 1MaleMalondialdehydeMyocardiumNF-E2-Related Factor 2Oxidative StressProbucolProtective AgentsAntioxidantsGlutathione PeroxidaseKEAP1 protein, ratKelch-Like ECH-Associated Protein 1MalondialdehydeNfe2l2 protein, ratNF-E2-Related Factor 2ProbucolProtective Agents

Identifiers

PMID29213348
PMCPMC5682903
OpenAlexW2765745723

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.