Evidence map›Paper›PMID 29213320›Full record

ArticleBiotechnology for biofuels2017

Metabolome analysis reveals a role for glyceraldehyde 3-phosphate dehydrogenase in the inhibition of

Liang Tian, Skyler J Perot, David Stevenson, Tyler Jacobson, Anthony A Lanahan, Daniel Amador-Noguez, Daniel G Olson, Lee R Lynd

Open access · goldAbstract read
In one paragraph

Article in Biotechnology for biofuels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  4. EngineeringbioRxiv : the preprint server for biology · 2025
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  5. The role of AdhE mutations inJournal of bacteriology · 2025
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  8. The potential of native and engineered Clostridia for biomass biorefining.Frontiers in bioengineering and biotechnology · 2024
    Review
  9. Ethanol tolerance in engineered strains of Clostridium thermocellum.Biotechnology for biofuels and bioproducts · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Utilization of Monosaccharides byMicroorganisms · 2021
    Article
  15. Article
  16. Effects of COBMC microbiology · 2020
    Article
  17. mSystems · 2020
    Article
  18. Metabolic and evolutionary responses ofBiotechnology for biofuels · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Liang TianThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755 USA.
Skyler J PerotDartmouth College, Hanover, NH 03755 USA.
David StevensonUniversity of Wisconsin-Madison, Madison, WI 53706 USA.
Tyler JacobsonUniversity of Wisconsin-Madison, Madison, WI 53706 USA.
Anthony A LanahanThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755 USA.
Daniel Amador-NoguezUniversity of Wisconsin-Madison, Madison, WI 53706 USA.
Daniel G OlsonThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755 USA.
Lee R LyndThayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755 USA.
Oak Ridge National Laboratory · USDartmouth College · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

resultsHere, we analyzed changes in the relative concentration of intracellular metabolites in response to gradual addition of ethanol to growing cultures. For

conclusionsWe have demonstrated that a metabolic bottleneck occurs at the GAPDH reaction when the growth of

Indexed as

Clostridium thermocellumConsolidated bioprocessingEthanol toleranceMetabolomic analysis

Identifiers

PMID29213320
PMCPMC5708176
OpenAlexW2769882599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.