Evidence map›Paper›PMID 29213239›Full record

ArticleFrontiers in pharmacology2017

Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity.

Sijia Yan, Yulan Lu, Lin He, Xinzhi Zhao, Lihua Wu, Huizhong Zhu, Menglin Jiang, Yu Su, Wei Cao, Weidong Tian and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sijia YanInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Yulan LuChildren's Hospital, Fudan University, Shanghai, China.
Lin HeInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Xinzhi ZhaoInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Lihua WuZhengzhou People's Hospital, Zhengzhou, China.
Huizhong ZhuInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Menglin JiangInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Yu SuInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Wei CaoZhengzhou Central Hospital, Zhengzhou University, Zhengzhou, China.
Weidong TianDepartment of Biostatistics and Computational Biology, School of Life Science, Fudan University, Shanghai, China.
Qinghe XingInstitutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNFudan University · CNZhengzhou Central Hospital · CNZhengzhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA editing is an important co- and post-transcriptional event that generates RNA and protein diversity. Aminoglycosides are a group of bactericidal antibiotics and a mainstay of antimicrobial therapy for several life-threatening infections. However, aminoglycosides can induce ototoxicity, resulting in damage to the organs responsible for hearing and balance. At low concentrations, aminoglycosides can bind to many RNA sequences and critically influence RNA editing. We used a bioinformatics approach to investigate the effect of aminoglycosides on global mRNA editing events to gain insight into the interactions between mRNA editing and aminoglycoside ototoxicity. We identified 6,850 mRNA editing sites in protein coding genes in embryonic zebrafish, and in about 10% of these, the degree of RNA editing changed more than 15% under aminoglycosides treatment. Twelve ear-development or ototoxicity related genes, including

Indexed as

aminoglycosides (AG)ototoxicityRNA-editingRNA-Seqzebrafish

Identifiers

PMID29213239
PMCPMC5702851
OpenAlexW2770360443

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.